Životopis/Biography Mladen Vranic

Official Contact Inforamtion Institution: University of Toronto, Department of Physiology Department Name: Medical Sciences Building Position : Professor of Physiology and Medicine Street And Number : 1 King's College Circle, Room 3358 ,  Toronto, Ontario M5S 1A8 ,  Canada Official Phone ,  Official Fax : 416-978-4126 ,  416-978-4940 E-mail mladen.vranic@utoronto.ca Web http://www.uoftphysiology.com   physiology (fundamental medical sciences.Biomedicine and Public Health) Education 1997 F.R.S.C. Fellow, Royal Society of Canada (Canadian Academy of Arts and Science) ,  ,  1992 M.D. (Hon.) Karolinska Institute Medical Faculty - Stockholm ,  Stockholm ,  Sweden 1986 F.R.C.P.(C) Fellow, Royal College of Physicians and Surgeons of Canada (Medical Scientist) ,  ,  1962 Postdoctoral Fellow Banting and Best Department of Medical Research, and Physiology Department, University of Toronto ,  ,  1962 D.Sc. (Ph.D. equivalent): Department of Physiology, Graduate School, University of Zagreb, ,  "Some modifications in the function and genesis of Langerhans Islets in animals with normal and atrophic exocrine pancreas". ,  Zagreb ,  1962 Dr.sc. University of Zagreb ,  Physiology Zagreb ,  Croatia (Hrvatska) 1955 University of Zagreb, Faculty of Medicine ,  Medical Training Zagreb ,  1955 M.D. University of Zagreb ,  Zagreb ,  Croatia (Hrvatska) Employment Positions 1991 - 1995 Chair Department of Physiology ,  ,  1987 Visiting Professor Faculty of Medicine, University of Zagreb, ,  Zagreb ,  Croatia (Hrvatska) 1986 Visiting Research Fellow, (Status) at the University of Oxford (6 month sabbatical leave) Merton College; M.A. ,  ,  1978 Professor of Medicine (cross-appointment) University of Toronto ,  Toronto ,  Canada 1977 Member Division of Endocrinology and Metabolism, Department of Medicine ,  ,  1976 - 1977 Professor (Invited) University of Geneva ,  ,  1973 - 1978 Member Institute of Biomedical Electronics & Engineering University of Toronto ,  ,  1973 Member Institute of Medical Science, University of Toronto ,  Toronto ,  Canada 1972 Professor of Physiology University of Toronto ,  Toronto ,  Canada 1968 - 1972 Associate Professor, Physiology, University of Toronto ,  Toronto ,  Canada 1968 Tenure University of Toronto ,  Toronto ,  Canada 1965 - 1968 Assistant Professor, Physiology, University of Toronto ,  Toronto ,  Canada Academic Positions Teaching Guest teacher 2003 Plenary Lecture 2nd Croatian Endocrinology Congress Plitvice ,  ,  2003 Almae Matris Croaticae Alumni ,  ,  2003 Citywide Endocrine Rounds ,  ,  2002 Scientific Forum of the University of Rijeka ,  University of Rijeka ,  ,  Rijeka ,  Croatia (Hrvatska) 2002 Lecture to Medical Association ,  Faculty of Medicine ,  ,  Zagreb ,  Croatia (Hrvatska) 2002 Glucagon as a Therapeutic Target, Amylin Pharmaceuticals, ,  ,  Chicago, Illinois ,  United States 2002 Scientific Forum Medical Faculty University of Zagreb ,  Faculty University of Zagreb ,  ,  Zagreb ,  Croatia (Hrvatska) 2001 Croatian Academy of Arts & Sciences ,  ,  Zagreb ,  Croatia (Hrvatska) 2001 2nd Croatian International Congress of Diabetology ,  ,  Dubrovnik ,  Croatia (Hrvatska) 2001 - Hypoglycemia 2001: From Research to Practice. Symposium of Juvenile Diabetes Research Foundation International ,  ,  Perugia ,  Italy 2001 Grand Rounds – University Health Network ,  University of Toronto ,  ,  Toronto ,  Canada 2001 City-wide Rounds ,  University of Toronto ,  Department of Medicine ,  Toronto ,  Canada 2001 Servier-IGIS Symposium on Kinetics of insulin release in health and type 2 diabetes. ,  ,  St. Jean-Cap-Ferrat ,  France 2000 Session Chair,  Physiology 2000: Past, Present, Future. ,  University of Toronto ,  Department of Physiology ,  Toronto ,  Canada 2000 University of Zagreb ,  Vuk Vrhovac Institute for Diabetes ,  Zagreb ,  Croatia (Hrvatska) 2000 - New Mexico Midwinter Study Group, Controversial Topics In Medicine, ,  ,  Alta, Utah ,  2000 Postgraduate Course in Endocrinology for Medical Doctors ,  University of Split ,  ,  Split ,  Croatia (Hrvatska) 2000 Department of Medicine ,  Boston University ,  ,  2000 American Diabetes Association Symposium on Physiology and Biochemistry of Exercise in insulin resistant states (Chair) ,  ,  San Antonio, Texas ,  1999 Co-Chair of Symposium, Session Chair and Lecturer,  New Aspects of Pathogenesis and Treatment of Diabetes Mellitus. The Fourth Toronto-Stockholm Symposium on Perspectives in Diabetes Research ,  ,  Stockholm ,  Sweden 1999 Lecturer,  Banting & Best Diabetes Centre Annual Diabetes Day Meeting ,  ,  Toronto ,  Canada 1999 Chair and Speaker,  Symposium on Glucocorticoid Antagonists ,  KaroBio AB Co., ,  ,  Tokyo ,  Japan 1999 New Mexico Midwinter Study Group, Controversial Topics In Medicine, ,  ,  Alta, Utah ,  1998 Academy of Science, Royal Society of Canada, The Fields Institute for Research in Mathematical Sciences ,  ,  1998 New Mexico Midwinter Study Group, Controversial Topics In Medicine, Ed Bierman Memorial Lecture, ,  ,  Alta, Utah ,  Mexico 1998 Societies for Endocrinology, Diabetes, Internal Medicine and Physiology, Croatian Medical Association ,  ,  Zagreb ,  Croatia (Hrvatska) 1998 University of Zagreb ,  Institute for Diabetes, Vuk Vrhovac ,  Zagreb ,  Croatia (Hrvatska) 1997 The New Mexico Mid Winter Study Group, Controversial Topics in Medicine. ,  ,  Alta, Utah ,  Mexico 1997 Symposium on FFA-glucose cycle, Canadian Society for Exercise Physiology ,  ,  Toronto ,  Canada 1997 Picower Institute ,  ,  Manhattan, New York ,  United States 1997 Session Chair: Symposium on In Vivo Measurement of Metabolic Processes. Prouts Neck, Maine. ,  ,  1997 Invited Special Lecture of Postgraduate Course wit,  Universities of Tokyo and Osaka ,  ,  Tokyo ,  Japan 1996 The New Mexico Mid Winter Study Group, Controversial Topics in Medicine. ,  ,  Alta, Utah ,  1996 Amgen Corporation, Thousand Oaks, ,  ,  California ,  1996 Post-graduate course in Diabetes organized by the Joslin Clinic and Loma Linda University, ,  ,  California ,  1996 New Aspects in Molecular Medicine ,  Croatian Academy of Science and Art ,  ,  Zagreb ,  Croatia (Hrvatska) 1995 Croatian Society for Diabetes and Other Metabolic Disorders ,  ,  Zagreb ,  Croatia (Hrvatska) 1995 Croatian Academy of Arts and Sciences ,  ,  Zagreb ,  Croatia (Hrvatska) 1995 The New Mexico Mid Winter Study Group, Controversial Topics in Medicine. ,  ,  Alta, Utah ,  1995 Poll Visiting Scholar and Lecturer ,  University of Washington ,  ,  Seattle ,  United States 1995 Novo Nordisk Lecture ,  Karolinska Institute ,  ,  Stockholm ,  Sweden 1995 Lecturer and panel discussion participant,  Towards the Discovery of Insulin. 75th Anniversary Symposium and 40th Anniversary of Turkish Diabetes Association. ,  ,  1995 Solomon A. Berson Distinguished Lectureship of The American Physiological Society. ,  ,  Atlanta, Georgia ,  1994 The New Mexico Mid Winter Study Group - Controversial Topics in Medicine ,  ,  Alta, Utah ,  1994 Chair,  Mini Symposium on Exercise, FASEB, ,  ,  Anaheim, California ,  Canada 1994 Invited lectures; visiting professor of the Loeb R,  University of Ottawa and Ottawa Civic Hospital ,  ,  1994 Invited speaker,  University of Kanazawa and Juntendo University ,  ,  Tokyo ,  Japan 1994 Chair and Speaker,  Exercise Symposium 15th IDF Congress ,  ,  Kobe ,  Japan 1994 Invited speaker of Satellite Symposium of 15th IDF,  "Glucose Fluxes, Exercise and Diabetes" ,  ,  Nara ,  Japan 1994 Seminar ,  University of Oxford ,  Nuffield Department of Clinical Medicine ,  Oxford ,  United States 1993 McGill Department of Physiology Seminar Series. ,  ,  1993 USC, Department of Physiology and Biophysics Seminar Series. ,  ,  Los Angeles ,  United States 1992 International Symposium on Atherosclerosis. ,  ,  Toronto ,  Canada 1992 The New Mexico Mid-Winter Study Group - Controversial Topics in Medicine, ,  ,  Alta, Utah ,  1992 North American Society of Obesity. Plenary Symposium. ,  ,  Atlanta, Georgia ,  1992 Co-Chair and Speaker,  Toronto-Stockholm Symposium on Diabetes Research, New Concepts in Pathogenesis of Diabetes ,  ,  Stockholm ,  Sweden 1992 Diabetes Meeting (Fukuoka), KINKI Diabetes Meeting (Osaka) and 2nd Symposium on Glucose Fluxes (Tokushima) ,  ,  1992 Invited Special Lectures in Japan to Kanto Study Group on Insulin Regimen ,  ,  Tokyo ,  Japan 1992 Mizuno Inaugural Lectureship. Fourth International Symposium on Exercise and Diabetes, ,  Osaka University ,  ,  1991 Howard Hughes Medical Institute and Molecular Physiology and Biophysics ,  Vanderbilt University ,  ,  Nashville ,  United States 1991 Medical Rounds ,  Mayo Clinic ,  ,  Rochester, Minnesota ,  1991 The New Mexico Mid-Winter Study Group - Controversial Topics in Medicine ,  ,  Alta, Utah ,  1991 Research Frontiers of Diabetes Mellitus, A Symposium for Canadian Medical Students, Halifax, Nova Scotia ,  ,  1991 2nd Annual Diabetes Symposium. Recent Advances in Diabetes Management. Diabetes Treatment Centre ,  ,  Modesto, California ,  1991 R. Kroc Lectureship ,  University of Southern California School of Medicine ,  ,  Los Angeles ,  United States 1991 Banting Lecture of the American Diabetes Association, 14th International Diabetes Federation Congress ,  ,  Washington ,  United States 1990 Plenary lecture,  IV International Symposium on Insulin Receptor and Insulin Action. ,  ,  Verona ,  Italy 1990 Annual Peter J. Laurie Memorial Lecture on Exercise and Diabetes, Juvenile Diabetes Foundation Canada. ,  ,  Canada 1990 Symposium Chair and Lecturer,  Toronto-Stockholm Symposium on Perspectives in Diabetes Research. The Nervous System and Fuel Homeostasis ,  ,  Toronto ,  Canada 1990 Symposium: Diabetes and its Complications ,  McGill University ,  ,  Montreal ,  Canada 1990 Session Chair and Speaker,  WHO Conference: Diabetes and Exercise '90. Supported by German Diabetes Association and EASD. ,  ,  Dusseldorf ,  Germany 1990 Lilly Visiting Professorship,  Lectures to Division of Endocrinology and Department of Physiology. ,  University of Michigan ,  ,  Michigan ,  1989 Speaker and Co-Organizer,  Toronto-Zagreb-Stockholm International Postgraduate Course on NIDDM held in Dubrovnik-Yugoslavia ,  ,  1989 Conference du Centre de Recherches en Nutrition et de la Faculte de Medecine ,  Universite Laval ,  ,  Quebec City ,  1989 First Kabi IGF-1 Workshop on Experimental Animal Data & Clinical Implications ,  ,  Stockholm ,  Sweden 1989 Co-Chair and Speaker,  Workshop on Tracer Methodology, Modelling and Application to Diabetes Mellitus ,  ,  Montebello ,  Canada 1989 Sandoz Research Institute, East Hanover, New Jersey, Lecture: "The Role of FFA-Glucose Cycle in Diabetes, Exercise & Stress: ,  ,  1989 Symposium on Type II Diabetes Mellitus. Royal College of Physicians and Surgeons and Canadian Society for Clinical Investigation ,  Clinical Investigation ,  ,  Ottawa ,  Canada 1987 - 1988 Chair and speaker,  7th International Biochemistry of Exercise Symp. on "Determinants of Extramuscular Substrate Utilization During Exercise", , Canada ,  ,  London ,  1987 - 1988 Keynote Speaker,  International Conference on Exercise, Fitness and Health, ,  ,  Toronto ,  Canada 1987 - 1988 Research Frontiers in Diabetes Mellitus: A Symposium for Medical Students, Royal Victoria Hospital ,  McGill University ,  ,  Montreal ,  1987 - 1988 Keynote Lecture commemorating the 60th Anniversary of the Institute for Diabetes "Vuk Vrhovac" ,  University of Zagreb ,  ,  Croatia (Hrvatska) 1987 - 1988 International Symposium on Diabetes Secondary to Pancreatopathy ,  ,  Padua ,  Italy 1987 - 1988 a) Exercise and Carbohydrate Metabolism Symposium ,  ,  1986 - 1987 Nobel Conference on Pathogenesis of NIDDM ,  ,  Stockholm ,  Sweden 1986 - 1987 Lecture Series of the Diabetes Centre ,  University of Pennsylvania ,  ,  Philadelphia ,  1986 - 1987 Postgraduate Diabetes Programme ,  Wayne State University on Update in Diabetes Management ,  ,  Detroit, Michigan ,  1986 - 1987 Canadian Association of Sports Sciences Symposium on Substrate Utilization in Exercise. ,  ,  Ottawa ,  Canada 1986 - 1987 I.U.P.S. Satellite Symposium on Human Adaptation to Prolonged Exercise. ,  ,  Toronto ,  Canada 1986 - 1987 Lecture Series of the Diabetes Centre, Role of Counterregulatory Hormones During Exercise. ,  Univ. Dusseldorf ,  ,  Dusseldorf ,  Germany 1985 - 1986 Symp. of the German Society for Internal Med. on New Aspects of Pathogenesis of Type II Diabetes, ,  ,  Wiesbaden ,  Germany 1985 - 1986 Visiting Professor, Japan. A) Keynote Lecture at G,  ,  1985 - 1986 Inaugural Banting and Best Memorial Lecture at the,  ,  1984 - 1985 Biochemistry of Exercise: 6th International Symposium ,  ,  Copenhagen ,  Denmark 1984 - 1985 Plenary Lecture at the 4th European Symposium on Metabolism, Padua, "New Perspectives Regarding the Significance of Insulin/glucagon Interaction in Control of Glucose Metabolism in Health and Diabetes". ,  ,  1984 - 1985 Pfizer Lecture at the Clinical Research Institute of Montreal, "The Role of Insulin and Counterregulatory Hormones in Exercise, Physiology and Diabetes". ,  ,  1984 - 1985 The Diabetic Athlete: Symposium of the Diabetes Educational and Clinical Research Centre, ,  ,  Kansas City, Kansas ,  1984 - 1985 Diabetes Research Centre Lecture Series on Research and Therapeutic Issues in Diabetes. "Effects of Exercise and Counterregulatory Hormones in Non-diabetic and Diabetic States". ,  University of Virginia, Charlottesville. ,  ,  1983 - 1984 Visiting Professorship,  Seattle; Lecturer, Diabetes Research Centre Lecture Series ,  University of Washington ,  ,  Washington ,  United States 1983 - 1984 Research Symposium on Diabetes and Exercise of the American Diabetes Association, ,  ,  Burlington, Vermont. ,  1982 - 1983 Diabetes Centre Lecture Series ,  Vanderbilt University ,  ,  Nashville, Tennessee ,  1982 - 1983 Juvenile Diabetes Foundation Workshop on Catecholamines and Metabolism. ,  ,  San Diego, California ,  1982 - 1983 Panel discussion on Exercise in Diabetes,  11th Congress of the International Diabetes Federation. ,  ,  Nairobi ,  Kenya 1982 - 1983 International Workshop in Jerusalem, Israel. Key,  Lessons from Animal Diabetes. ,  ,  1982 - 1983 Toronto International Workshop on Insulin and Portable Delivery Systems ,  ,  Toronto ,  Canada 1981 - 1982 Federation of Am. Societies for Experimental Biology Symp. on Fuel Utilization During Exercise ,  ,  New Orleans, Louisiana ,  1981 - 1982 Diabetes Research and Training Centre Seminar Seri,  University of Virginia ,  ,  Charlottesville, Virginia ,  1981 - 1982 Symposium on the Treatment of Diabetes Mellitus in the 1980's. Am. Diabetes Ass'n. Western N.Y. Affiliate, Buffalo. ,  ,  1981 - 1982 Memorial Symposium. (60th Anniversary of Insulin), "Diabetes and Insulin". ,  University of Toronto ,  ,  Toronto ,  Canada 1981 - 1982 G.J. Friedman Symposium of the American Diabetes Association. New York Diabetes Affiliate ,  ,  New York ,  United States 1980 - 1981 Third European Symposium on Metabolism. ,  ,  Padua ,  Italy 1980 - 1981 Mount Sinai School of Medicine Symposium on Atherosclerosis and Diabetes. ,  ,  New York ,  United States 1980 - 1981 Third International Symposium on Advances in Paediatric Research on Current Views on the Etiology and Pathogenesis of IDDM ,  University of Toronto ,  ,  Toronto ,  Canada 1980 - 1981 Satellite Symposium of the Third International Congress of Obesity on the Impact of Obesity on Hyperlipoproteinemia and Diabetes Mellitus ,  ,  Dusseldorf ,  Germany 1980 - 1981 Diabetes and Exercise Symposium of the European Association for the Study of Diabetes ,  ,  Olympia ,  Greece 1980 - 1981 Memorial Symposium of the Tore Nilson Foundation for Medical Research ,  Karolinska Institute on Metabolic Risk Factors in Atherosclerosis ,  ,  Stockholm ,  Sweden 1979 - 1980 Upjohn Lecturer of the Faculty of Health Sciences, "Effects of Exercise in Diabetes". ,  University of Ottawa ,  ,  1979 - 1980 Satellite Symposium of the Tenth Congress of the International Diabetes Federation; Delivery of Health Care for Diabetics in Developing Countries. ,  ,  Dubrovnik ,  Croatia (Hrvatska) 1979 - 1980 Tenth Congress of the International Diabetes Federation. Panel on Exercise and Diabetes ,  ,  Vienna ,  Austria 1979 - 1980 International Workshop on Quantitative Physiology and Modelling in Carbohydrate Metabolism ,  ,  Padua ,  Italy 1978 - 1979 Workshop on Potential of Exercise in Maintenance Dialysis. ,  National Institute of Health ,  ,  Bethesda, Maryland ,  1978 - 1979 Second European Symposium on Hypoglycemia ,  ,  Rome ,  Italy 1978 - 1979 4th Int'l Symposium on Early Diabetes ,  ,  Algarve ,  Portugal 1978 - 1979 Ninth Canadian Diabetes Workshop ,  ,  Toronto, Ontario ,  Canada 1978 - 1979 Fifth Postgraduate Course on Diabetes. European Association for the Study of Diabetes ,  ,  Zagreb ,  Croatia (Hrvatska) 1977 - 1978 Symposium of the American Diabetes Association on Fuel Metabolism and Exercise ,  ,  Boston ,  1976 - 1977 Conference of J.H. Macy Scholars, ,  ,  Cambridge, England. ,  1976 - 1977 Int'l Lecture Series on Metabolism, Insulin Glucagon Interactions and Control of Glucose Turnover. ,  University of Padova ,  ,  Padova ,  Italy 1976 - 1977 Vuk Vrhovac Memorial Lecture ,  Univ. of Zagreb ,  ,  Zagreb ,  Croatia (Hrvatska) 1976 - 1977 Satellite Glucagon Symposium of the International Diabetes Federation ,  ,  Srinagar ,  India 1975 - 1976 International Glucagon Symposium, ,  ,  Dallas, Texas. ,  1975 - 1976 Symposium of the Royal College of Physicians and Surgeons of Canada on Gut Hormones ,  ,  Quebec City ,  1975 - 1976 Symposium of the Canadian Diabetes Association on Glucose Homeostasis ,  ,  Quebec City ,  1975 - 1976 4th Int'l Donau Symp. on Diabetes Mellitus. ,  ,  Dubrovnik ,  Croatia (Hrvatska) 1975 - 1976 Tokyo Diabetes Association. ,  ,  Tokyo ,  Japan 1975 - 1976 Visiting Professor,  "Metabolic Role of Glucagon in Health and Disease". ,  University of Osaka ,  ,  Osaka ,  Japan 1975 - 1976 Visiting Professor,  "Gut: A New Source of Glucagon". ,  University of Kobe ,  ,  Kobe ,  Japan 1975 - 1976 Symposium on Diabetes Mellitus in Asia. ,  ,  Kyoto ,  Japan 1974 - 1975 Kroc Foundation Symposium on Advances in Glucagon Research ,  ,  Santa Ynez, California ,  1973 - 1974 American College of Sports Medicine, Symposium on Hormonal Responses in Exercise. ,  ,  Knoxville, Tennessee ,  1973 - 1974 Canadian Hoechst Workshop on Diabetes, Quebec ,  ,  1973 - 1974 Eighth Congress of International Diabetes Federation, Brussels. Workshop on Exercise, Fuels and Hormones and Panel on Regulation of Metabolic Fuel Supply. ,  ,  1973 - 1974 Symposium on Dynamics and Control in Physiological Systems ,  American Physiological Society, IFAC ,  ,  Rochester. ,  :: :: - :: :: Special lecture, 2nd Croatian Meeting of Internal Medicine ,  ,  Opatija ,  Croatia (Hrvatska) Congres 2001 2nd Croatian International Congress on Diabetology, ,  ,  Dubrovnik ,  Croatia (Hrvatska) 2000 Physiology 2000: Past, Present, Future. ,  Department of Physiology, University of Toronto ,  ,  Toronto ,  Canada 1999 The 4th Toronto-Stockholm Symposium on Perspectives in Diabetes Research: New aspects of pathogenesis and treatment of diabetes mellitus ,  ,  Stockholm ,  Sweden 1996 Member of Scientific Advisory Board, New Aspects in Molecular Medicine 3. Molecular Endocrinology ,  ,  Zagreb ,  Croatia (Hrvatska) 1996 Organizing Committee for Symposium on Perspectives in Diabetes Research Commemorating 75th Anniversary of Discovery of Insulin. ,  University of Toronto, Karolinska Institute Stockholm, and Joslin Center - Harvard University, Boston. ,  ,  Toronto, Boston ,  Canada 1995 Organizing Committee for Symposium Celebrating Discovery of Insulin in Istanbul Turkey, ,  ,  1994 Advisory board, Symposium on Glucagon and Related Peptides, ,  ,  Osaka ,  Japan 1994 Glucose Fluxes, Exercise and Diabetes ,  Honorary Chair of Satellite Symposium of 15th IDF Congress ,  ,  Nara ,  Japan 1992 2nd Toronto-Stockholm Symposium on Perspectives in Diabetes Research - New Concepts in Pathogenesis of NIDDM ,  ,  Stockholm ,  Sweden 1991 Diabetes Mellitus and Exercise Satellite Symposium of the 14th Congress of International Diabetes Federation, ,  ,  Burlington ,  United States 1990 Toronto-Stockholm Symposium on Perspectives in Diabetes Research. ,  The Nervous System and Fuel Homeostasis. ,  ,  Toronto ,  Canada 1989 Postgraduate Course on Type II Diabetes under the auspices of IDF and WHO Dubrovnik ,  Zagreb-Toronto-Stockholm Int’l. ,  ,  Dubrovnik ,  Croatia (Hrvatska) 1989 Workshop on Tracer Methodology ,  Modelling and Application to Diabetes Mellitus ,  ,  Montebello ,  Canada 1988 Scientific Programme Advisory Committee, 13th Congress of International Diabetes Federation ,  ,  Sydney ,  Australia 1988 Scientific Committee, International Symposium on Diabetes Secondary to Pancreatopathy ,  ,  Padua ,  Italy 1985 Scientific Programme Advisory Committee, 12th Congress of the International Diabetes Federation, ,  ,  Madrid ,  Spain 1985 Organizing Committee of the Symposium on Obesity and Diabetes. ADA and North American Association ,  Study of Obesity ,  ,  Toronto ,  Canada 1984 Comparison of Type I and Type II Diabetes: Similarities and Dissimilarities in Etiology, Pathogenesis and Complications. Satellite Symposium of the VIIth International Congress of Endocrinology. ,  ,  Toronto ,  Canada 1982 Scientific Programme Advisory Committee, 11th Congress of the International Diabetes Federation ,  ,  Nairobi ,  Kenya 1981 Symposium on the Quantitative Dynamic Regulation of Metabolism in Physiology and Diabetes. Canadian and American Physiological Societies, ,  ,  Toronto ,  Canada 1980 Ad hoc Committee to plan first Joint Meeting of American and Canadian Physiological Society. ,  ,  1978 Kroc Foundation Symposium on Exercise and Diabetes. ,  ,  California ,  1975 Tracer Methodology Group Conference on Glucose Recycling and Gluconeogenesis. FASEB, ,  ,  Atlantic City ,  1974 Tracer Methodology Group Conference on FFA and Lipoproteins. FASEB, ,  ,  Atlantic City ,  Projects :: :: - :: :: JUVENILE DIABETES FOUNDATION INTERNATIONAL ,  Physiological and molecular mechanisms of counterregulatory dysfunction in hypoglycemia :: :: - :: :: (Continuing, uninterrupted support for 41 years) Canadian Institutes of Health Research ,  ,  Mechanism of impaired hypothalamic-pituitary-adrenal axis and its responsiveness to hypoglycemia, exercise and stress in diabetes: adaptive changes in brain, pituitary, pancreas, adrenal medulla and muscle. Publications Articles Mladen   Vranic Park EK, Chan O, Kiraly, M, Matthews SG, Riddell MC. Initial upregulation of basal pituitary-adrenal activity during aerobic training in normal rats may be restored by decreased corticotrophin-releasing hormone (CRH) and glucocorticoid receptor (GR) mRNA ,  (In preparation) ,  2004 Mladen   Vranic Chan O, Inouye K, Akirav EM, Park EK, Riddell MC, Matthews SG. Diabetes lowers the ceiling for maximal activation of the hypothalamo-pituitary-adrenal axis in response to stress. ,  Endocrinology (in revision). ,  2004 Mladen   Vranic Chan O, Inouye K, Akirav EM, Park EK, Riddell, MC, Matthews SG Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal (HPA) activity in diabetes, but it does impair the HPA response to insulin-induced hypoglycemia. ,  (submitted). ,  2004 Mladen   Vranic Inouye K, Chan O, Yue JTY, Matthews SG. Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal (HPA) axis. ,  Am J Physiol Endocrinol Metab (submitted) ,  2004 Mladen   Vranic Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG. Partial leptin restoration markedly improves metabolic profile in STZ-diabetic rats. ,  Metabolism (in press) ,  2004 Mladen   Vranic Kreisman SH, Halter JB, Marliss E. Combined infusion of epinephrine and norepinephrine during moderate exercise reproduces the glucoregulatory response of intense exercise. ,  Diabetes ,  2003 ,  52: 1347-1354 Mladen   Vranic Chan O, Inouye K, Riddell MC, Matthews SG. Diabetes and the hypothalamic-pituitary-adrenal (HPA) axis. ,  Minerva Endocrinologia ,  2003 ,  28: 87-102 Mladen   Vranic Chan O, Chan S, Inouye K, Shum K, Bilinski D, Matthews SG. Diabetes impairs hypothalamic-pituitary-adrenal (HPA) responses to hypoglycemia and insulin treatment normalizes HPA, but not epinephrine responses. ,  Diabetes ,  2002 ,  51: 1681-1689 Mladen   Vranic Inouye K, Chan O, Riddell MC, Akirav E, Matthews SG. Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: Reduced counterregulatory responsiveness to hypoglycemia. Diabetes, Nutrition & Metabolism: ,  Clinical and Experimental ,  2002 ,  15: 348-356 Mladen   Vranic Inouye K, Shum K, Chan O, Mathoo J, Matthews SG. Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. ,  Am J Physiol Endocrinol Metab ,  2002 ,  282: E1369-E1379 Mladen   Vranic Chan O, Inouye K, Matthews SG. Hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis in STZ-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. ,  Endocrinology ,  2002 ,  143: 1761-1768 Mladen   Vranic Marliss EB. Intense exercise has unique effects on both insulin release and its role in glucoregulation: Implications for diabetes. ,  Diabetes ,  (Suppl. 1) ,  2002 ,  51 S271-S283 Mladen   Vranic Chan O, Chan S, Inouye K, Matthews SG. Molecular regulation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-induced diabetes: effects of insulin treatment. ,  Endocrinology ,  2001 ,  142: 4872-4879 Mladen   Vranic Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Matthews SG. Effects of antecedent hypoglycemia, hyperinsulinemia and excess corticosterone on hypoglycemic counterregulation. ,  Am J Physiol (Endocrinol Metab) ,  2001 ,  281: :E455-E465 Mladen   Vranic Kreisman S, New NA, Halter JB, Marliss EB. Norepinephrine infusion during moderate intensity exercise increases glucose production and uptake. ,  J Clin Endocrinol Metab ,  2001 ,  86: 2118-2124 Mladen   Vranic Carpentier A, Patterson BW, Uffelman KD, Giacca A, Cattral MS., Lewis GF. The effects of systemic vs. portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism. ,  Diabetes ,  2001 ,  50: 1402-1413 Mladen   Vranic Fisher SJ, Shi ZQ, Lickley HLA, Efendic S, Giacca A. Low-dose IGF-1 has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic, depancreatized dogs. ,  J Endocrinol ,  2001 ,  168: 49-58 Mladen   Vranic Niwa, M., Rashid, S., Shum, K. Mathoo, J., Tchipasvuku, V., Chan, O., Kawamori, R., Giacca, A. The effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs. ,  Metabolism ,  2000 ,  49: 862-867 Mladen   Vranic Kreisman SH, Mew NA, Arsenault M, Nessim SJ, Halter JB, Marliss EB. Epinephrine infusion during moderate intensity exercise increases glucose production and uptake. ,  Am J Physiol (Endocrinol Metab) ,  2000 ,  278: E949-957 Mladen   Vranic Kreisman SH, Manzon A, Nessim SJ, Morais JA, Gougeon R, Fisher SJ, Marliss EB. Glucoregulatory responses to intense exercise performed in the postprandial state. ,  Am J Physiol (Endocrinol Metab) ,  2000 ,  278: E786-793 Mladen   Vranic Marliss EB, Kreisman SH, Manzon A, Halter JB, Nessim SJ. Gender differences in glucoregulatory responses to intense exercise. ,  J Appl Physiol ,  2000 ,  88: 457-466 Mladen   Vranic Sigal RJ, Fisher SJ, Manzon A, Morais JA, Halter JB, Marliss EB. Glucoregulation during and after intense exercise: effects of alpha-adrenergic blockade. ,  Metabolism ,  2000 ,  49: 386-394 Mladen   Vranic Rashid S, Shi ZQ, Niwa M, Mathoo JMR, Vanderlangeryt M, Bilinski D, Lewis G. Beta-blockade but not normoglycemia nor hyperinsulinemia markedly diminished stress-induced hyperglycemia in diabetic dogs. ,  Diabetes ,  2000 ,  49 253-262 Mladen   Vranic Sigal RJ, Fisher SJ, Halter JB, Marliss EB. Glucoregulation during and after intense exercise: effects of beta-adrenergic blockade in subjects with type 1 diabetes mellitus. ,  JCEM ,  1999 ,  84: 3961-3971 Mladen   Vranic Mathoo, J.M.R., Shi, Z.Q., Klip, A. Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle. ,  Diabetes ,  1999 ,  48: 1281-1288 Mladen   Vranic Marette, A., Dimitrakoudis, D., Shi, Z.Q., Rodgers, C.D., Klip, A. Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle. ,  Endocrine ,  10 ,  1999 ,  (1) 13-18 Mladen   Vranic Lewis, G.H., Carpentier, A., Lamarche, B., Bilinski, D., Giacca, A. Counterregulatory response to insulin-induced hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans. ,  J Clin Endo Metab. Rapid Communication ,  1999 ,  84: 1037-1046 Mladen   Vranic Lewis, G.H., Carpentier, A., Giacca, A. Resistance to insulin’s direct hepatic effect in suppressing steady state glucose production in individuals with type 2 diabetes mellitus. ,  Diabetes ,  1999 ,  48: 570-576 Mladen   Vranic Lekas, M., Fisher, S., Van Delangeryt, M., Shi, Z.Q. Glucose uptake during centrally induced stress is insulin independent and enhanced by -blockade. ,  J. Applied Physiol ,  1999 ,  87: 722-731 Mladen   Vranic Sandhu, H., Wiesenthal, S.R., McCall, R.H., Tchipashvili, V., Rashid, S., Satkunarajah, M. Irwin, D.M., Shi, Z.Q., Brubaker, P.L., Wheeler, M.B., Efendic, S., Giacca, A. Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. ,  Diabetes ,  1999 ,  48: 1045-1053 Mladen   Vranic Rodgers CD. Mediation of glucoregulation at rest and during exercise by the glucose-fatty cycle in vivo and in vitro studies. ,  Can J Appl Physiol ,  33 ,  1998 ,  (6) 534-537 Mladen   Vranic Manzon, A., Fisher, S., Morais, J., Lipscombe, L., Guimond, M.C., Nessim, S., Sigal, R., Halter, J.B., E.B. Marliss. Glucose infusion partially attenuates glucose production and increases glucose uptake during intense exercise. ,  J. Applied Physiol. ,  85 ,  1998 ,  (2) 514-524 Mladen   Vranic Lewis, G.F., Giacca, A., G. Steiner. Acute direct and indirect effects of insulin on hepatic glucose and very low density lipoprotein (VLDL) production – ,  Current opinions in Endocrinology and Diabetes ,  1998 ,  5: 235-245 Mladen   Vranic Lewis, G.F., A. Giacca. Role of free fatty acids and glucagon in the peripheral effect of insulin on hepatic glucose production in humans. ,  Am. J. Physiol (Endocrinol. & Metab.) ,  1998 ,  275 E177-E186 Mladen   Vranic Rastogi, K.S., Cooper, R.L., Shi, Z.Q. Quantitative measurement of islet glucagon response to hyperglycemia by confocal fluorescence imaging in diabetic rats: effect of phlorizin treatment. ,  Endocrine ,  1997 7 367-375 Mladen   Vranic Fisher, S.J., Lekas, M., Shi, Z.Q., Bilinski, D., Carvalho, G., Giacca, A. Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs. ,  Diabetes ,  1997 ,  46 1805-1812 Mladen   Vranic Lewis, G.F., Harley, P., Giacca A. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. ,  Diabetes ,  1997 ,  46 1111-1119 Mladen   Vranic Lewis, G., Giacca, A. Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans. ,  Am. J. Physiol. (Endocrinol. & Metab.) ,  1997 ,  272: E371-E378 Mladen   Vranic Giacca, A., Fisher, S., McCall, R.H., Shi, Z.Q. Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: Role of glucagon. ,  Endocrinology ,  1997 ,  138: 999-1007 Mladen   Vranic Matsuhisa, M., Shi, Z.Q., Wan, C., Lekas, M., Rodgers, C., Giacca, A., Kawamori, R. The effect of pioglitazone on hepatic and peripheral glucose uptake in alloxan-induced diabetic dogs. ,  Diabetes ,  1997 ,  46 224-231 Mladen   Vranic Pigon, J., Giacca, A., Ostenson, C.G., Lam, L., Efendic, S. Normal hepatic insulin sensitivity in mild lean non-insulin dependent diabetes. ,  J. Clin. Endocr. Metab. ,  1996 ,  81: 3701-3708 Mladen   Vranic Shi, Z.Q., Rastogi, K.S., Lekas, M., Efendic, S., Drucker, D.J. Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats. ,  Endocrinology ,  1996 ,  137: 3193-3199 Mladen   Vranic Tsakiridis, T., Wong, P.P.C., Liu, Z., Rodgers, C.D., Klip, A. Exercise increases the plasma membrane content of Na+/K+pump and its mRNA of in rat skeletal muscles. ,  J. Applied Physiol. ,  80 ,  1996 ,  (2) 699-705 Mladen   Vranic Lewis, G., Zinman, B., Groenwould, Y., Giacca, A. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. ,  Diabetes ,  1996 ,  45: 454-462 Mladen   Vranic Fisher, S., Lekas, M.D., McCall, Shi, Z.Q., R.H, Giacca, A. Determinants of glucose turnover in pathophysiology and diabetes: An in vivo analysis in diabetic dogs. ,  Diabetes and Metabolism ,  1996 ,  22: 111-121 Mladen   Vranic Fisher, S., Shi, Q., Lickley, L., Efendic, S., Giacca, A. A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp. ,  Metabolism ,  45 ,  1996 ,  (5) 587-593 Mladen   Vranic Sigal, R.J., Fisher, S., Halter, J.B., Marliss, E.B. The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique. ,  Diabetes ,  1996 ,  45: 148-156 Mladen   Vranic Tsakiridis, T., McDowell, H.W., Walker, T., Downes, C.P., Hundal, H.S., Klip, A. Multiple roles of phophatidylinositol 3-kinase in the regulation of glucose transport, amino acid transport and glucose transporters in L-6 skeletal muscle cells. ,  Endocrinology ,  1995 ,  136: 4315-22 Mladen   Vranic Tsakirides, T., Klip, A. Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by uncoupling the oxidative chain: Comparison with insulin action. ,  Biochem. J. ,  1995 ,  309: 1-5 Mladen   Vranic Pigon, J., Efendic, S., Ostenson, C., Lam, L., Giacca, A. Insulin-stimulated glucose uptake is enhanced in sedentary and endurance trained low insulin responders. ,  Am. J. Physiol. (Endocrinol. Metab. 29) ,  268 ,  1995 E1046-E1050 Mladen   Vranic Tsakiridis, T., Klip, A. Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters in plasma membrane. ,  J. Biol. Chem. ,  1994 ,  269: 29934-29942 Mladen   Vranic Shi, Z.Q., Giacca, A., Fisher, S., Hubert Vidal, van de Werve, G. Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog. ,  Diabetes ,  1994 ,  43: 1284-1290 Mladen   Vranic Sigal, R., Purdon, C., Fisher, S., Halter, J.B., Marliss, E.B. Hyperinsulinemia prevents prolonged hyperglycemia by correcting glucose metabolic clearance following intense exercise in insulin-dependent diabetic subjects. ,  J. Clin. Endocr. Metab. ,  79 ,  1994 ,  (No.4) 1049-1057 Mladen   Vranic Miles, P.D.G., Yamatani, K., Brown, M.P., Lickley, A. Intracerebroventricular administration of somatostatin octapeptide counteracts the hormonal and metabolic responses to stress in normal and diabetic dogs. ,  Metabolism ,  1994 ,  43: 1134-1143 Mladen   Vranic Giacca, A., Fisher, S., Shi, Z.Q., Gupta, R., Lickley, H.L.A., Skottner, A., Anderson, G.H., Efendic, S. Insulin-like growth factor-I and insulin have no differential effects on glucose production and utilization under conditions of hyperglycemia. ,  Endocrinology ,  1994 ,  134: 2251-2258 Mladen   Vranic Sigal, R., Purdon, C., Bilinski, D., Halter, J.B., Marliss, E.B. Glucoregulation during and after intense exercise: Effects of -blockade. ,  J. Clin. Endocr. Metab. ,  1994 ,  78: 359-366 Mladen   Vranic Rastogi, K.S., Brubaker, P.L., Kawasaki, A., Efendic, S. Increase in somatostatin to glucagon ratio in alloxan diabetic dogs: Effect of insulin-induced euglycemia. ,  Can. J. Physiol. Pharmacol. ,  1993 ,  71: 512-517 Mladen   Vranic Purdon, C., Brusson, M., Nyreen, S.L., Miles, P.D.G., Halter, J., Marliss, E.B. The roles of insulin and catecholamines in the glucoregulatory response during intense exercise and early recovery in insulin-dependent diabetic and control subjects. ,  J. Clin. Endocr. Metab. ,  1993 ,  76: 566-573 Mladen   Vranic Shi, Z.Q., Giacca, A., Yamatani, K., Fisher, S., Lickley, L. Effects of subbasal insulin infusion on resting and exercise-induced glucose uptake in depancreatized dogs. ,  Am. J. Physiol. (Endocrinol. Metab. 27): ,  264 ,  1993 E334-341 Mladen   Vranic Lavoie, L., Dimitrakoudis, D., Marette, A., Annali, B., Klip, A., Van de Werve, G. Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthesis phosphatase activity in the diabetic rat. ,  Diabetes ,  1993 ,  42: 363-366 Mladen   Vranic Marette, A., Burdett, E., Douen, A., Klip, A. Insulin induces the translocation of GLUT 4 glucose transporters from a unique intracellular organelle to transverse tubules in rat skeletal muscle. ,  Diabetes ,  1992 ,  41: 1562-1569 Mladen   Vranic Giacca, A., Fisher, S., Gupta, R., Shi, Z.Q., Lickley, L. Importance of peripheral mechanisms of insulin action for the regulation of hepatic glucose production in diabetes. ,  J. Clin. Invest. ,  1992 ,  90: 1769-1777 Mladen   Vranic Dimitrakoudis, D., Klip, A. Effects of hyperglycemia on glucose transporters of the muscle: Use of the renal glucose reabsorption inhibitor phlorizin to control glycemia. ,  J. Am. Soc. Nephrol. ,  1992 ,  3: 1078-1091 Mladen   Vranic Glucose turnover: A key to understanding the pathogenesis of diabetes. Indirect effects of insulin. The Banting Lecture. ,  Diabetes ,  41 ,  1992 ,  (9) 1188-1206 Mladen   Vranic Marette, A., Richardson, J.M., Ramlal, T., Balon, T.W., Pessin, J.F., Klip, A. Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle of rat hind limb. ,  Am. J. Physiol. (Cell Physiol. 32) ,  1992 ,  263 C443-C452 Mladen   Vranic Marliss, E.B., Simantirakis, E., Miles, P.D.G., Hunt, R., Gougeon, R., Purdon, C., Halter, J.B. Glucose turnover and its regulation during intense exercise and recovery in normal male subjects. ,  Clin. and Invest. Med. ,  1992 ,  15: 406-419 Mladen   Vranic Yamatani, K., Shi, Z., Giacca, A., Gupta, R., Fisher, S., Lickley, L. Role of FFA-Glucose cycle in glucoregulation during exercise in total absence of insulin. ,  Am. J. Physiol., (Endocrinol. Metab. 26): ,  263 ,  1992 E646-E653 Mladen   Vranic Wajngot, A., Giacca, A., Grill, V., Efendic, S. The diabetogenic effects of glucocorticoids are more pronounced in low than in high insulin responders. ,  Proc. Natl. Acad. Sci. USA ,  1992 ,  89: 6035-6039 Mladen   Vranic Dimitrakoudis, D, Ramlal, T., Rastogi, S., Klip, A. Glycemia regulates the glucose transporter number in the plasma membrane of rat skeletal muscle. ,  Biochem. J. ,  1992 ,  284: 341-348 Mladen   Vranic Miles, P., Finegood, D.T., Lickley, L. Regulation of glucose turnover at the onset of exercise in dogs. ,  J. Applied Physiol. ,  1992 ,  72: 2487-2494 Mladen   Vranic Finegood, D.T., Miles, P., Lickley, L. Estimation of hepatic glucose production during exercise with a one-compartment, variable-volume model of glucose kinetics. ,  J. Applied Physiol., ,  1992 ,  72: 2501-2509 Mladen   Vranic Klip, A., Marette, A., Dimitrakoudis, D., Ramlal, T., Giacca, A., Shi, Z. Effect of diabetes on glucoregulation. From glucose transporters to glucose metabolism in vivo. ,  Diabetes Care ,  1992 ,  15: 1747-1766 Mladen   Vranic Marliss, E.B., Simantirakis, E., Miles, P.D.G., Purdon, C., Gougeon-Reyburn, R., Field, C.J., Halter, J.B. Glucoregulatory and hormonal responses to repeated bouts of intense exercise in normal male subjects. ,  J. Appl. Physiol., ,  71 ,  1991 ,  (3) 924-933 Mladen   Vranic Brubaker, P., Kazumi, T., Hirano, T., Steiner, G. Failure of chronic hyperinsulinemia to suppress pancreatic glucagon in vivo in the rat. ,  Can. J. Physiol. Pharm. ,  69 ,  1991 ,  (3) 437-443 Mladen   Vranic Miles, P., Yamatani, K., Lickley, L. Mechanism of glucoregulatory responses to stress and their deficiency in diabetes. ,  Proc. Natl. Acad. Sci. U.S.A., ,  88 ,  1991 ,  (4) 1296-1300 Mladen   Vranic Douen, A.G., Burdett, E., Ramlal, T., Rastogi, S., Klip, A. Characterization of glucose transporter enriched membranes from rat skeletal muscle: assessment of endothelial cell contamination, and of presence of sarcoplasmic reticulum and transverse tubules. ,  Endocrinology ,  1991 ,  128: 611-616 Mladen   Vranic Douen, A.G., Ramlal, T., Rastogi, S., Bilan, P.J., Cartee, G.D., Holloszy, J.O., Klip, A. Exercise induces recruitment of the insulin responsive glucose transporter. Evidence for distinct intracellular insulin and exercise-recruitable transporter pools in skeletal muscle. ,  J. Biol. Chem. ,  1990 ,  265: 13427-13430 Mladen   Vranic Wajngot, A., Khan, A., Giacca, A., Efendic, S. Dexamethasone increases glucose cycling, but not glucose production in healthy subjects. ,  Am. J. Physiol. (Endocrinol. Metab.) ,  259 ,  1990 ,  22: E626-E632 Mladen   Vranic Giacca, A., Gupta, R., Efendic, S., Hall, K., Scottner, A., Lickley, L. Differential effects of IGF-I and insulin on glucoregulation and fat metabolism in depancreatized dogs. ,  Diabetes ,  1990 ,  39: 340-347 Mladen   Vranic Rastogi, K.S., Lickley, L., Jokay, M., Efendic, S. Paradoxical reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic dogs: a putative mechanism of glucagon irresponsiveness to hypoglycemia. ,  Endocrinology ,  1990 ,  126: 1096-1104 Mladen   Vranic Ramlal, T., Rastogi, S., Klip, A. Decrease in glucose transporter number in skeletal muscle of mild diabetic (streptozotocin-treated) rats. ,  Endocrinology ,  1989 ,  125: 890-897 Mladen   Vranic Karlander, S.G., Khan, A., Wajngot, A., Torring, O., Efendic, S. Glucose turnover in hyperthyroid patients with normal glucose tolerance. ,  J. Clin. Endocrinol. Metab. ,  68 ,  1989 ,  (4) 780-786 Mladen   Vranic Challis, R.A.J., Radda, G.K. Bioenergetic changes during contraction and recovery in diabetic rat skeletal muscle. ,  Am. J. Physiol. ,  1989 ,  256: E129-E137 Mladen   Vranic Hetenyi, G. Jr., Gauthier, C., Byers, M. Phlorizin-induced normoglycemia partially restores glucoregulation in diabetic dogs. ,  Am. J. Physiol. ,  1989 ,  256: E277-E283 Mladen   Vranic Bjorkman, O., Miles, P., Wasserman, D., Lickley, L. Regulation of glucose turnover during exercise in pancreatectomized, totally insulin deficient dogs: effects of ?-adrenergic blockade. ,  J. Clin. Invest. ,  1988 ,  81: 1759-1767 Mladen   Vranic Finegood, D.T., Bergman, R.N. Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. ,  Diabetes ,  1988 ,  37: 1025-1034 Mladen   Vranic Efendic, S., Karlander, S. Mild Type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity. ,  J. Clin. Invest. ,  1988 ,  81: 1953-1961 Mladen   Vranic Some perspectives regarding the neuroendocrine control of carbohydrate metabolism in diabetes mellitus. Special lecture commemorating the 60th Anniversary of Diabetes Institute, University of Zagreb. ,  Diabetologia Croatica ,  1988 ,  17-3 189-205 Mladen   Vranic El Tayeb, K.M.A., Brubaker, P.L., Lickley, H.L.A. Beta endorphin modulation of the glucoregulatory effects of repeated epinephrine infusion in alloxan-diabetic and normal dogs. ,  Diabetologia ,  1987 ,  30: 745-754 Mladen   Vranic Brubaker, P.L. Glucagon-like immunoreactive peptides in a rat ileal epithelial cell line (IEC-18). ,  Endocrine Research ,  13 ,  1987 ,  (3) 229-241 Mladen   Vranic Lickley, H.L.A., Kemmer, F.W., El-Tayeb, K.M.A. Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs. ,  Diabetologia ,  1987 ,  30: 175-182 Mladen   Vranic Finegood, D.T., Bergman, R.N. Estimation of endogenous glucose production during hyperinsulinemic euglycemic glucose clamps: Comparison of unlabeled and labeled exogenous glucose infusates. ,  Diabetes ,  1987 ,  36: 914-924 Mladen   Vranic Hanna, A., Zinman, B. Glucose turnover in insulinoma: a case report. ,  Diabetes Res. and Clinical Practice ,  1987 ,  3: 111-114 Mladen   Vranic Brubaker, P., Sun, A. Lack of effect of beta-endorphin on basal or glucagon-stimulated hepatic glucose production in vitro. ,  Metabolism ,  1987 ,  36: 432-437 Mladen   Vranic Rastogi, S., Efendic, S., Lickley, L., Kovacevic, N. Elevated somatostatin in pancreatic islets of adrenalectomized dogs. ,  Endocrinology ,  1987 ,  120: 544-548 Mladen   Vranic Brubaker, P.L. Fetal rat intestinal cells in monolayer culture: a new in vitro system to study glucagon-like immunoreactive peptides. ,  Endocrinology ,  1987 ,  120: 1976-1985 Mladen   Vranic Karlander, S., Efendic, S. Increased glucose turnover and glucose cycling in acromegalic patients with normal glucose tolerance. ,  Diabetologia ,  1986 ,  29: 778-783 Mladen   Vranic Kazumi, T., Bar-On, H., Steiner, G. Portal v. peripheral hyperinsulinemia and very low density lipoprotein triglyceride kinetics. ,  Metabolism ,  1986 ,  35: 1024-1028 Mladen   Vranic Karlander, S., Roovete, A., Efendic, S. Glucose and fructose 6-phosphate cycle in humans. ,  Am. J. Physiol. (Endocrinol. Metab. 14) ,  1986 ,  251: E530-E536 Mladen   Vranic Cooper, D.M., Wasserman, D.H., Wasserman, K. Glucose turnover response to exercise during high and low FI02 breathing in man. ,  Am. J. Physiol. (Endocrinol. Metab. 14) ,  1986 ,  251: E209-E214 Mladen   Vranic El-Tayeb, K.M.A., Gauthier, C.J.T., Brubaker, P.L., Lickley, H.L.A. Hormonal and metabolic responses to intracarotid and intrajugular infusion of beta-endorphin in normal dogs. ,  Cdn. J. Physiol. Pharmacol. ,  1986 ,  64: 306-310 Mladen   Vranic Gauthier, C., El-Tayeb, K., Lickley, H.L.A. Glucoregulatory role of cortisol and epinephrine interactions studied in adrenalectomized dogs. ,  Am. J. Physiol. (Endocrinol. Metab. 13) ,  1986 ,  250: E393-E401 Mladen   Vranic Kazumi, T., Steiner, G. Triglyceride kinetics: effects of dietary glucose, sucrose and fructose alone or with hyperinsulinemia. ,  Am. J. Physiol. (Endocrinol. Metab. 13) ,  1986 ,  250: E325-E330 Mladen   Vranic El-Tayeb, K.M.A., Brubaker, P.L., Lickley, H.L.A., Cook, E. Effect of opiate receptor blockade on normoglycemic and hypoglycemic glucoregulation. ,  Am. J. Physiol. (Endocrinol. Metab. 13) ,  1986 ,  250: E236-E242 Mladen   Vranic Lussier, B., Kovacevic, N., Hetenyi, G. Jr. Glucoregulation in alloxan-diabetic dogs. ,  Metabolism ,  1986 ,  35: 18-24 Mladen   Vranic El-Tayeb, K.M.A., Brubaker, P.L , Lickley, H.L.A. Beta endorphin modulation of the glucoregulatory effects of repeated epinephrine infusion in normal dogs. ,  Diabetes ,  1985 ,  34: 1293-1300 Mladen   Vranic Kazumi, T., Steiner, G. Changes in very low density lipoprotein particle size and production in response to sucrose feeding and hyperinsulinemia. ,  Endocrinology ,  1985 ,  117: 1145-1150 Mladen   Vranic Wasserman, D.H., Lickley, H.L.A. The role of beta-adrenergic mechanisms during exercise in poorly-controlled diabetes. ,  J. Appl. Physiol. ,  59 ,  1985 ,  (4) 1282-1289 Mladen   Vranic Wasserman, D.H., Lickley, H.L.A. Important role of glucagon during exercise in diabetic dogs. ,  J. Appl. Physiol. ,  59 ,  1985 ,  (4) 1272-1281 Mladen   Vranic Efendic, S., Wajngot, A. Increased activity of the glucose cycle in the liver: early characteristic of Type II diabetes. ,  Proc. Natl. Acad. Sci. USA ,  1985 ,  82: 2965-2969 Mladen   Vranic Lussier, B., Gauthier, C., Hetenyi, G. Jr. Glucoregulation in dogs treated with methyl-prednisolone. ,  Metabolism ,  1985 ,  34: 906-91 Mladen   Vranic Wasserman, D.H., Lickley, H.L.A. Effect of hematocrit reduction on hormonal and metabolic responses to exercise. ,  J. Appl. Physiol. ,  58 ,  1985 ,  (4) 1257-1262 Mladen   Vranic Hatton, T.W., Yip, C.C. Biosynthesis of glucagon (IRG3500) in canine gastric mucosa. ,  Diabetes ,  1985 ,  34: 38-46 Mladen   Vranic Wasserman, D.H., Lickley, H.L.A. Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. ,  J. Clin. Invest. ,  1984 ,  74: 1404-1413 Mladen   Vranic Gauthier, C., Bilinski, D., Wasserman, D., El Tayeb, K., Hetenyi, G. Jr., Lickley, H.L.A. Catecholamine responses and their interactions with other glucoregulatory hormones. ,  Am. J. Physiol. (Endocrinol. Metab. 10) ,  1984 ,  247 E145-E156 Mladen   Vranic Steiner, G., Haynes, F., Yoshimo, G. Hyperinsulinemia and in vivo VLDL triglyceride turnover. ,  Am. J. Physiol. (Endocrin. Metab. 9) ,  1984 ,  264 E187-E192 Mladen   Vranic Radziuk, J., Kemmer, F., Morishima, T., Berchtold, P. The effects of acarbose, an alpha-glucoside hydrolase inhibitor on glycemia and absorption of sucrose in man determined using a tracer method. ,  Diabetes ,  1984 ,  33: 207-213 Mladen   Vranic Lins, P.E., Wajngot, A., Adamson, U., Efendic, S. Minimal increases in glucagon level enhance glucose production in man with partial hypoinsulinemia. ,  Diabetes ,  1983 ,  32: 633-636 Mladen   Vranic Lickley, H.L.A., Kemmer, F.W., Doi, K. Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes. ,  Am. J. Physiol. (Endocrin. Metab. 8) ,  1983 ,  245 E424-E429 Mladen   Vranic Gauthier, C., Hetenyi, G. Jr. Non-hypoglycemic glucoregulation: role of glycerol and glucoregulatory hormones. ,  Am. J. Physiol. (Endocrin. Metab. 7) ,  1983 ,  244 E373-E379 Mladen   Vranic Kemmer, F.W., Sirek, A., Sirek, O.V., Perez, G. Glucoregulatory mechanisms following hypophysectomy in diabetic dogs with residual insulin secretion. ,  Diabetes ,  1983 ,  32: 26-34 Mladen   Vranic Hetenyi, G. Jr., Perez, G. Turnover and precursor-product relationships of non-lipid metabolites. ,  Physiological Reviews ,  1983 ,  63: 606-667 Mladen   Vranic Wajngot, A., Roovete, A., Luft, R., Efendic, S. Insulin resistance and decreased insulin response to glucose in lean Type II diabetics. ,  Proc. Natl. Acad. Sci. U.S.A. ,  1982 ,  79: 4432-4436 Mladen   Vranic Wajngot, A., Luft, R., Efendic, S. Glucose metabolism in basal state and during a two-hour glucose infusion in low insulin responders and control subjects. ,  Horm. Metab. Res. ,  1982 ,  14: 564-568 Mladen   Vranic Hatton, T.W., Kovacevic, N., Dutczak, M. Glucagon-like immunoreactants in extracts of the rat hypothalamus. ,  Endocrinology ,  1982 ,  111: 572-577 Mladen   Vranic Zinman, B., Marliss, E.B., Hanna, A.K., Minuk, H.L. Exercise in diabetic man: glucose turnover and "free" insulin responses after glycemic normalization with intravenous insulin. ,  Cdn. J. Physiol. Pharmacol. ,  1982 ,  60: 1236-1240 Mladen   Vranic Steiner, G., Marliss, E.B., Zinman, B. Glucoregulation in obese man: effects of fasting, glucagon infusion, exercise and diabetes. ,  Int. J. Obesity ,  1982 ,  6 (Suppl. I) 55-71 Mladen   Vranic Steiner, G. Hyperinsulinemia and hypertriglyceridemia, a vicious cycle with atherogenic potential. ,  Int. J. Obesity (Suppl. I) ,  1982 6 117-124 Mladen   Vranic Kemmer, F.W., Lickely, H.L.A., Gray, D.E., Perez, G. The state of metabolic control determines the role of epinephrine-glucagon interactions of glucoregulation in diabetes. ,  Am. J. Physiol. (Endocrin. Metab. 4) ,  1982 ,  242 E428-E436 Mladen   Vranic Zinman, B. The heterogeneous response to exercise in diabetes mellitus. ,  Mount Sinai Journal of Medicine ,  49 ,  1982 ,  (3) 250-257 Mladen   Vranic Lickley, H.L.A., Kemmer, F.W., Gray, D.E., Kovacevic, N., Hatton, T.W., Perez, G. Chromatographic pattern of extrapancreatic glucagon and glucagon-like immunoreactivity before and during stimulation by epinephrine and participation of glucagon in epinephrine-induced hepatic glucose overproduction. ,  Surgery ,  90 ,  1981 ,  (2) 186-194 Mladen   Vranic Perez, G., Kemmer, F.W., Lickley, H.L.A. Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs. ,  Am. J. Physiol. (Endocrinol. Metab. 4) ,  1981 ,  241 E328-E335 Mladen   Vranic Minuk, H.L., Marliss, E.B., Hanna, A.K., Albisser, A.M., B. The glucoregulatory and metabolic response to exercise in obese non-insulin dependent diabetes. ,  Am. J. Physiol. (Endocrinol. Metab.): ,  1981 ,  240 E458-E464 Mladen   Vranic Steiner, G., Morita, S. Resistance to insulin but not glucagon in lean human hypertriglyceridemics. ,  Diabetes ,  1980 ,  29: 899-905 Mladen   Vranic Gray, D., Lickley, L. Physiological effects of epinephrine on glucose turnover and plasma free fatty acid levels independent of glucagon. ,  Diabetes ,  1980 ,  29: 600-609 Mladen   Vranic Morita, S., Steiner, G. Insulin resistance in obesity analyzed by the response of glucose kinetics to glucagon infusion. ,  Diabetes ,  1980 ,  29: 169-176 Mladen   Vranic Issekutz, B. Role of glucagon in the regulation of glucose production in exercising dogs. ,  Am. J. Physiol. ,  1980 ,  238: E13-E20 Mladen   Vranic Gauthier, C., Hetenyi, G. Jr. Importance of glucagon in regulatory rather than emergency responses to hypoglycemia. ,  Am. J. Physiol. ,  1980 ,  238: E131-140 Mladen   Vranic Minuk, H.L., Hanna, A.K., Marliss, E.B., Zinman, B. Metabolic response to moderate exercise in obese man during prolonged fasting. ,  Am. J. Physiol. ,  1980 ,  238: E322-E329 Mladen   Vranic Sirek, A., Sirek, O., Vigas, M. and Policova, A. The effect of growth hormone on acute glucagon and insulin release. ,  Am. J. Physiol. ,  1979 ,  237: E107-E112 Mladen   Vranic Coce, R., Femenic, R., Skrabalo, A. The effect of repetitive exercise on daily control of glycemia in insulin-dependent diabetics. ,  Advances in Experimental Medicine and Biology ,  1979 ,  119: 453-462 Mladen   Vranic Doi, K., Prentki, M., Yip, C., Muller, W., Jeanrenaud, B., Identical biological effects of pancreatic glucagon and a purified moiety of canine gastric glucagon. ,  J. Clin. Invest. ,  1979 ,  63: 525-531 Mladen   Vranic Berger, M., Halban, P.A., Assal, J.P., Offord, R.E., Renold, A.E. Pharmacokinetics of subcutaneously injected tritiated insulin: effects of exercise. ,  Diabetes ,  (Suppl. I): ,  1979 ,  28 53-57 Mladen   Vranic Lickley, H.L.A., Ross, G.G. Effects of selective insulin or glucagon deficiency on glucose turnover. ,  Am. J. Physiol. ,  236 ,  1979 ,  (3) E255-E262 Mladen   Vranic Berger, M. Exercise and diabetes mellitus. ,  Editorial. Diabetes ,  1979 ,  28: 147-167 Mladen   Vranic Horvath, S., Wahren, J. Exercise and diabetes: an overview. ,  Diabetes (Suppl. I) ,  1979 ,  28 107-110 Mladen   Vranic Kawamori, R. Essential roles of insulin and glucagon in control of glucose fluxes during exercise in dogs: mechanism of hypoglycemia. ,  Diabetes (Suppl. I) ,  1979 ,  28 45-52 Mladen   Vranic Zinman, B., Albisser, M., Leibel, B. and Marliss, E. The role of insulin in the metabolic response to exercise in diabetic man. ,  Diabetes, (Suppl. I) ,  1979 ,  28 76-81 Mladen   Vranic Zinman, B., Albisser, A.M., Hanna, A., Minuk, H.L., Marliss, E.B. Exercise and insulin absorption. ,  New England Journal of Medicine ,  298 ,  1978 ,  (21) 1202 Mladen   Vranic Muller, W.A., Girardier, L., Seydoux, J., Berger, M., Renold, A.E. Extrapancreatic glucagon and glucagon-like immunoreactivity in depancreatized dogs: a quantitative assessment of secretion rates and anatomical delineation of sources. ,  J. Clin. Invest. ,  1978 ,  62: 124-132 Mladen   Vranic Berger, M., Halban, P.A., Muller, W.A., Offord, R.E., Renold, A.E. Mobilization of subcutaneously injected tritiated insulin in rats: effect of muscular exercise. ,  Diabetologia ,  1978 ,  15: 113-140 Mladen   Vranic Lickley, H.L.A., Track, N.S., Bury, K.D. Metabolic responses to enteral and parenteral nutrition. ,  Am. J. Surgery ,  1978 ,  135: 172-175 Mladen   Vranic Ross, G., Lickley, L. Extrapancreatic glucagon in control of glucose turnover in depancreatized dogs. ,  Am. J. Physiol. ,  234 ,  1978 ,  (2) E213-E219 Mladen   Vranic Radziuk, J., Norwich, K.H. Experimental validation of measurements of glucose turnover in nonsteady state. ,  Am. J. Physiol. ,  1978 ,  234: E84-E93 Mladen   Vranic Exercise in the therapy of diabetes mellitus ,  Diabetologia Croatica (Suppl. II): ,  1978 225-239 Mladen   Vranic Ravazzola, M., Baetens, D., Engerman, R., Kovacevic, N., Orci, L. Endocrine cells in oxyntic mucosa of a dog 5 years after pancreatectomy. ,  Hormone and Metabolic Research ,  1977 ,  9: 480-483 Mladen   Vranic Zinman, B., Murray, F.T., Albisser, M., Leibel, B.S., McClean, P.A., Marliss, E. Glucoregulation during moderate exercise in insulin treated diabetics. ,  J. Clin. Endocrinol. Metab. ,  1977 ,  45: 641-652 Mladen   Vranic Streja, D., Steiner, G., Marliss, E. Turnover and recycling of glucose in man during prolonged fasting. ,  Metabolism ,  1977 ,  26: 1089-1098 Mladen   Vranic Garfinkel, P.E., Warsh, J.J., Stancer, H.C., Godse, D.D., Brown, G.N. The effect of peripheral decarboxylase inhibitor (carbidopa) on monamine and neuroendocrine function. ,  Neurology ,  1977 ,  27: 443-447 Mladen   Vranic Radziuk, J. A note on estimating rapid changes in the rate of glucose production from glycogenolysis and recycling through lactate. ,  Fed. Proc. ,  1977 ,  36: 236-238 Mladen   Vranic Kawamori, R. Mechanisms of exercise-induced hypoglycemia in depancreatized dogs maintained on long acting insulin. ,  J. Clin. Invest. ,  1977 ,  59: 331-337 Mladen   Vranic Steiner, G., Wilson, D. Studies of glucose turnover and renal function in an unusual case of hereditary fructose intolerance. ,  Am. J. Med. ,  1977 ,  62: 150-153 Mladen   Vranic Ross, G., Doi, K., Lickley, L. The role of glucagon-insulin interactions in control of glucose turnover and its significance in diabetes. ,  Metabolism ,  25 (Suppl. I) ,  1976 1375-1380 Mladen   Vranic Engerman, R., Doi, K., Morita, S., Yip, C.C. Extrapancreatic glucagon in the dog. ,  Metabolism ,  25 (Suppl. I): ,  1976 1469-1473 Mladen   Vranic Hetenyi, G. Jr., Kovacevic, N., Hall, S.E.H. Plasma glucagon in pups, decreased by fasting, unaffected by somatostatin or hypoglycemia ,  Am. J. Physiol. ,  1976 ,  231: 1377-1382 Mladen   Vranic Morita, S., Doi, K., Yip, C. Measurement and partial characterization of immunoreactive glucagon in gastrointestinal tissues of dogs. ,  Diabetes ,  1976 ,  25: 1018-1025 Mladen   Vranic Kawamori, R., Pek, S., Kovacevic, N., Wrenshall, G.A. The essentiality of insulin and the role of glucagon in regulating glucose turnover during strenuous exercise. ,  J. Clin. Invest. ,  1975 ,  57: 245-255 Mladen   Vranic Kuksis, A., Kovacevic, N., Lau, D. Turnover of plasma oleic acid by radio-gas chromatography. ,  Fed. Proc. ,  1975 ,  34: 2238-2241 Mladen   Vranic Kawamori, R., Wrenshall, G.A. The role of insulin and glucagon in regulating glucose turnover in dogs during exercise. ,  Medicine and Science in Sport ,  1975 ,  7: 27-33 Mladen   Vranic Turnover of free fatty acids and triglyceride: an overview ,  Fed. Proc.: ,  1975 2233-2237 Mladen   Vranic Pek, S., Kawamori, R. Increased "glucagon immunoreactivity" in plasma of totally depancreatized dogs ,  Diabetes ,  1975 ,  23: 905-912 Mladen   Vranic Cherrington, A.D., Kawamori, R., Pek, S. Arginine infusion in dogs: model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. ,  Diabetes ,  1974 ,  23: 805-815 Mladen   Vranic Radziuk, J., Norwich, K. Measurement and validation of nonsteady turnover rates with application to the inulin and glucose system. ,  Fed. Proc. ,  1974 ,  33: 1855-1864 Mladen   Vranic Tracer methodology and glucose turnover: an overview. ,  Fed. Proc. ,  1974 ,  33: 1837-1840 Mladen   Vranic Cherrington, A. Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. ,  Metabolism ,  1974 ,  23: 729-744 Mladen   Vranic Norwich, K., Radziuk, J., Lau, D. Experimental validation of nonsteady rate measurements using a tracer infusion method and insulin as tracer and tracee. ,  Cdn. J. Physiol. Pharmacol. ,  1973 ,  52: 508-521 Mladen   Vranic Cherrington, A.D. Effect of arginine on glucose turnover and plasma free acids in normal dogs. ,  Diabetes ,  1973 ,  22: 537-543 Mladen   Vranic Cherrington, A., Fono, P., Kovacevic, N. Effect of glucagon on glucose turnover and free fatty acids in depancreatized dogs maintained on matched insulin infusions ,  Cdn. J. Physiol. Pharmacol. ,  1972 ,  50: 946-954 Mladen   Vranic Fono, P., Kovacevic, N., Lin, B.J. Glucose kinetics and fatty acids in dogs on matched insulin infusion after a glucose load. ,  Metabolism ,  1971 ,  20: 954-967 Mladen   Vranic Cherrington, A., Role of glucagon and insulin in the control of glucose turnover. ,  Metabolism ,  1971 ,  20: 625-628 Mladen   Vranic Ishiwata, A.K., Hetenyi, G., Effect of D-ribose or D-glucose on the turnover of glucose in pancreatectomized dogs maintained on matched intraportal insulin. ,  Diabetes ,  1969 ,  18: 820-827 Mladen   Vranic Wrenshall, G.A. Exercise, insulin and glucose turnover in dogs ,  Endocrinology ,  1969 ,  85: 165-171 Mladen   Vranic Cowan, J.S., Wrenshall, G.A. Effects of preceding diet and fasting on glucose turnover in normal dogs. ,  Metabolism ,  1969 ,  18: 319-330 Mladen   Vranic Rappaport, A.M., Campbell, J., Green, G.R., Cowan, J.S., Wrenshall, G.A. Effects of hepatic artery ligation on survival and metabolism of partially and totally depancreatized dogs. ,  Am. J. 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The effects of sudden deprivation and restoration of insulin secretion on glucose metabolism in dogs. ,  Diabetes ,  1965 ,  14: 689-695 Mladen   Vranic Cowan, J.S., Wrenshall, G.A. Nutritional conditions affecting the rates of glucose production in fed and fasting female dogs ,  Metabolism ,  1965 ,  14: 468-470 Mladen   Vranic The effects of cortisol on guinea pigs with normal and atrophic exocrine prancreas ,  Diabetes ,  1965 ,  14: 194-200 Mladen   Vranic Skarpa, D. The effects of cortisol on carbohydrate metabolism and Langerhans islets in guinea pigs. ,  Bull. Sci. Conseil Acad. RSF Yugoslavie ,  1964 9 160 Mladen   Vranic Pokrajac, N. The effect of age and fasting on blood sugar levels in normal and adrenalectomized rats. ,  J. Gerontol. ,  1961 ,  16 110-113 Mladen   Vranic Rabadjija, L., Allegretti, N. Uber die Phosphatasenaktivitat in Pankreas und Serum bei Meerschweinchen. ,  Hoppe-Seyler's Z. Physiol. 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Bergman, Verlag ,  Munchen 1986 ,  546-558 Mladen   Vranic Changes in some concepts regarding endocrine control of carbohydrate metabolism since Banting and Best. Inaugural Banting and Best Memorial Lecture. ,  Diabetes 1985, Proceedings of the 12th Congress of the International Diabetes Federation, Madrid, Spain, September 1985 (eds. M. Serrano-Rios and P.J. Lefebvre). ,  Excerpta Medica International Congress Series No. 700, 1986 ,  11-24 Mladen   Vranic Wasserman, D. Interaction between insulin and counter-regulatory hormones in control of substrate utilization in health and diabetes during exercise. ,  Diabetes/Metabolism Reviews (ed. R.A. DeFronzo). vol. 1 (no. 4), ,  J. Wiley Inc., 1986 ,  159-183 Mladen   Vranic Wasserman, D. Interaction between insulin, glucagon and catecholamines in the regulation of glucose production and uptake during exercise: physiology and diabetes. ,  In: Biochemistry of Exercise VI (ed. B. Saltin). International Series of Sports Sciences. ,  Human Kinetics Pubs., Champaign, Ill. 1986 ,  167-179 Mladen   Vranic Cherrington, A.D. Hormonal control of gluconeogenesis in vivo. ,  In: Hormonal Regulation of Gluconeogenesis. vol. 1, Ch. 2 (ed. N. Kraus-Friedman) ,  CRC Press, 1986 ,  15-37 Mladen   Vranic Lickley, H.L.A. ; Davidson, J.K. Exercise and stress in diabetes mellitus. ,  In: Clinical Diabetes Mellitus: A Problem Oriented Approach (ed. J.K. Davidson). ch. 15 ,  Thieme-Stratton Inc., ,  N.Y. 1986 ,  172-205 Mladen   Vranic Comparison between Type I and Type II diabetes: Similarities and dissimilarities in etiology, pathogenesis and complications. ,  Advances in Experimental Medicine and Biology, vol. 189. (Ed.M. Vranic, G. Steiner and C.H. Hollenberg) ,  Plenum Press ,  New York 1985 Mladen   Vranic Wasserman, D. ; Lickley, H.L.A. Role of glucagon-insulin interaction in control of carbohydrate metabolism: significance of glucagon in hypoinsulinemia. ,  4th European Symposium on Metabolism. (ed. G. Crepaldi, A. Tiengo and G. Baggio) ,  Elsevier ,  Amsterdam 1985 ,  305-317 Mladen   Vranic Wajngot, A. ; Efendic, S.E. New probes to study insulin resistance in man: futile cycles and glucose turnover. ,  In: Comparison of Type I and Type II Diabetes: Similarities and Dissimilarities in Etiology, Pathogenesis and Complications. Advances in Experimental Medicine and Biology, (eds. M. Vranic, G. Steiner, C.H. Hollenberg). vol. 189 ,  Plenum Press ,  N.Y. 1985 ,  227-245 Mladen   Vranic Identification of some issues and questions to be answered in comparing Type I and Type II diabetes ,  In: Comparison of Type I and Type II Diabetes: Similarities and Dissimilarities in Etiology, Pathogenesis and Complications. Advances in Experimental Medicine and Biology, (eds. M.C Vranic, G. Steiner, C.H. Hollenberg). vol. 189 ,  Plenum Press ,  N.Y. 1985 ,  1-15 Mladen   Vranic Zinman, B. Diabetes and exercise. ,  In: Symposium on Medical Aspects of Exercise (eds. L. Goldberg, D.L. Elliot). Medical Clinic of North America Vol. 69. ,  W.B. Saunders Co. ,  W.B. Saunders Co., 1985 ,  145-157 Mladen   Vranic Lickley, H.L.A. ; Kemmer, F.W. ; Sirek, O. ; Sirek, A. The diabetic dog: a model for the study of interaction between the counter- regulatory hormone and insulin. ,  Lessons from Animal Diabetes. Ed. E. Shafrir, and A. Renold ,  John Libbey ,  London & Paris 1984 ,  321-329 Mladen   Vranic Lickley, H.L.A. ; Kemmer, F.W. ; Perez, G. Interactions between insulin and the counterregulatory hormones in normal physiology, stress, and diabetes. ,  In: Recent Advances in Obesity and Diabetes Research. (Ed. N. Melchionda, D.L. Horwitz and D.S. Schade) ,  Raven Press ,  N.Y. 1984 ,  269-281 Mladen   Vranic Hall, S.E.H., Braaten, J.T., Bolton, T., Thoden, J. Substrate utilization during normal and loading diet treadmill marathons. ,  In: Biochemistry of Exercise (ed. H.G. Knuttgen, J.A. Vogel, J. Poostmans). International Series of Sports Sciences. Vol. 13. ,  Human Kinetics Pubs. ,  Champaign, Ill. 1983 ,  536-542 Mladen   Vranic Lickley, H.L.A. Control of fuel fluxes in health and diabetes: exercise versus stress. ,  Diabetes 1982, Proceedings of the 11th Congress of the International Diabetes Federation. Ed. E.N. Mngola, International Congress Series No. 600 ,  Excerpta Medica ,  Amsterdam 1983 ,  533-541 Mladen   Vranic Lickley, H.L.A. ; Kemmer, F.W. ; Wasserman, D. Glucagon and its relationship to other glucoregulatory hormones in exercise and stress in normal and diabetic subjects. ,  In: Glucagon II: Handbook of Experimental Pharmacology. Vol. 66/II. (Ed. P.J. Lefebvre) ,  Springer-Verlag ,  Berlin, Ch. 1983 ,  297-350 Mladen   Vranic Lickley, H.L.A. ; Kemmer, F.W. ; Perez, G. Hormonal interactions in the regulation of glucose fluxes in stress and diabetes ,  In: Diabetes, Obesity and Hyperlipidemias II. (ed. G. Crepaldi, P.J. Lefebvre and D.J. Galton). ,  Academic Press 1983 ,  361-383 Mladen   Vranic Kemmer, F.W. ; Berchtold, P. ; Berger, M. Hormonal interaction in control of metabolism during exercise in physiology and diabetes. ,  In: Diabetes Mellitus: Theory and Practice, 3rd Ed. Ed. H. Ellenberg and H. Rifkin. ,  Medical Examination Pub. Co., (Excerpta Medica), Ch. 27, ,  N.Y. 1983 ,  567-590 Mladen   Vranic Radziuk, J. ; Kemmer, F. ; Berchtold, P. Quantitation of the effects of the alpha-glucosidase inhibitor acarbose on the hydrolysis and absorption of sucrose and hormone response in man. ,  In: Effects on Carbohydrate and Fat Metabolism (ed. W. Creutzfeldt). ,  International Congress Series 594, Excerpta Medica ,  Amsterdam 1983 ,  113-122 Mladen   Vranic Zinman, B. ; Marliss, E.B. Peripheral insulinemia and the glucoregulatory response to exercise in diabetic man. ,  In: Current Problems in Clinical Biochemistry: 11, Diabetes and Exercise. Eds. M. Berger, P. Christacopoulos and J. Wahren, ,  Hans Huber Pub. ,  Bern 1982 ,  45-56 Mladen   Vranic Lickley, L. ; Kemmer, F.W. ; Perez, G. ; Gray, D. Insulin- glucagon-epinephrine interaction in regulation of glucose fluxes in normal and diabetic dogs. ,  In: Metabolic Risk Factors in Ischemic Cardiovascular Disease. Ed. L.A. Carlson and B. Pernow ,  Raven Press ,  N.Y. 1982 ,  159-183 Mladen   Vranic Lickley, H.L.A. ; Kemmer, F.W. ; Perez, G. ; Hetenyi, G. Jr. ; Hatton, T.W. ; Kovacevic, N. Interactions between insulin and the counterregulatory hormones in the development of diabetes mellitus. ,  In: Etiology and Pathogenesis of Insulin Dependent Diabetes Mellitus (ed. J.M. Martin, R.M. Ehrlich and F.J. Holland) ,  Raven Press ,  N.Y. 1981 ,  153-178 Mladen   Vranic Hormonal control of glucose fluxes during exercise: an overview. ,  In: Workshop on the Potential of Exercise in Maintenance Dialysis. Proc. of the 12th Ann. Contractors' Conference on artificial kidney program of the National Institute of Arthritis, Metabolism and Digestive Diseases (ed. B.B. Mackay) NIH Publications No ,  1981 ,  153-178 Mladen   Vranic Lickley, L. ; Gray, D. ; Gauthier, C. ; Mihic, N. ; Hetenyi, G. Jr. Interaction between glucagon, insulin and epinephrine in control of glucose turnover in normal and diabetic dogs. ,  Carbohydrate Metabolism. Ed. C. Cobelli and R.N. Bergman. Quantitative Physiology and Modelling. ,  J. Wiley and Sons 1981 ,  169-196 Mladen   Vranic Kemmer, F.W. The role of glucagon and its relationship to other glucoregulatory hormones in exercise. ,  Contemporary Endocrinology Series. Ed. R.H. Unger and L. Orci. ,  Elsevier North-Holland Inc. ,  N.Y., 1981 ,  297-331 Mladen   Vranic Zinman, B. Insulin regulation of glucose flux during exercise. Diabetes, 1979. ,  Proceedings of the 20th Congress of the International Diabetes Federation. Excerpta Medica International Congress Series No. 500. Ed. W.K. Waldhausl. ,  ,  Amsterdam 1980 ,  333-338 Mladen   Vranic Issekutz, B. The important roles of glucagon and insulin in regulation of glucose fluxes in health and diabetes. ,  In: Current views on hypoglycemia and glucagon. Ed. D. Andreani, P.J. Lefebvre and V. Marks. ,  Academic Press ,  London 1980 ,  57-70   Proceedings of a conference on diabetes and exercise. ,  Diabetes 28, Suppl. 1, (Ed.M. Vranic, J. Wahren and S. Horvath) ,  1979 ,  1-113 Mladen   Vranic Halban, P. ; Berger, M. ; Gjinovci, A. ; Renold, A. ; Offord, R.E. Pharmokinetics of subcutaneously injected semi-synthetic tritiated insulin in rats ,  . In: Semisynthetic peptides and proteins. Ed. Offord, R.E. and Di Bello, C. ,  Academic Press ,  London 1978 ,  237-246 Mladen   Vranic Muller, W.A., Girardier, L., Seydoux, J., Berger, J., Renold, A.E. Extrapancreatisches Glucagon und Glucagon ahnliche immunoreaktivitat (GLI) beim pancreatektomierten Hund. ,  Karlsburger Sympos. uber Diabetes. Ed. H. Zuhlke und U. Poser ,  1978 ,  108-111   Glucose recycling and gluconeogenesis. ,  Fed. Proc. (Ed. C.F. Ramberg and M. Vranic) ,  1977 ,  225-270 Mladen   Vranic Doi, K. ; Baba, S. ; Yip, C.C. Purification and biosynthesis of canine gastric glucagon. ,  Proceedings of the Symp. on Chemical Physiology and Pathology, Vol. 17, ,  ,  Tokyo, Japan 1977 ,  2-7 Mladen   Vranic Yip, C., Doi, K., Lickley, L., Morita, S., Ross, G. The role of interaction between insulin and glucagon (pancreatic and extrapancreatic) in the regulation of glucose turnover in physiology and in the diabetic state ,  In: Glucagon: Its Role in Physiology and Clinical Medicine. Ed. P.O. Foa, J.S. Bajaj, and N.L. Foa ,  N.Y. ,  Springer-Verlag 1977 ,  403-436 Mladen   Vranic Kawamori, R., Pek, S., Radziuk, J., Kovacevic, N., Wrenshall, G.A. Role of insulin and glucagon in regulating glucose turnover and the mechanisms of hypoglycemia occurring during strenuous exercise ,  In: Diabetes Mellitus in Asia. Ed. S. Baba and C.N. Hales ,  Excerpta Medica International Congress Series. ,  Amsterdam 1976 ,  380-395   Turnover of free fatty acids and triglyceride. ,  Fed. Proc. (ed. M. Vranic) ,  1975 ,  2233-2270 Mladen   Vranic Radziuk, J., Norwich, K. Input identification in metabolic systems with an application to the glucose system ,  In: Proceedings of the Summer Computer Simulation Conference ,  La Jolla, CA ,  Simulation Councils 1975 ,  906-911   Tracer methodology and glucose turnover. ,  Fed. Proc. (ed. M. Vranic) ,  1974 ,  1837-1876 Mladen   Vranic Cherrington, A. The regulation of glucose turnover (mobilization and supply) and FFA concentration by insulin-glucagon interaction in dogs ,  In: Diabetes. Ed. J. Pirart and W. Malaisse ,  Excerpta Medica International Congress Series No. 312 ,  Amsterdam 1974 ,  256-270 Mladen   Vranic Radziuk, J., Cherrington, A. The role of glucagon and insulin in the glucoregulatory system as assessed by tracer methods ,  In: Regulation and Control in Physiological Systems. International Federation of Automatic Control. Ed. A.S. Iberall and A.C. Guyton ,  Distributed by Instrument Society of America ,  Pittsburgh 1973 ,  487-490 Mladen   Vranic Insulin and glucagon: A dual feedback system to control glucose homeostasis ,  In: Insulin Action. Ed. I.B. Fritz ,  Academic Press ,  N.Y., Ch. 21 1972 ,  529-541 Mladen   Vranic Pokrajac, N. Tolbutamide hypoglycaemia in normal rats of different age ,  IV Congress of the International Diabetes Federation ,  ,  Geneva 1961 ,  735-738 Mladen   Vranic Pokrajac, N., Rabadjija, L. Allegretti, N. Die Zellenrelation in den Langerhanschen Inseln der Ratte in verschiedenen Lebensaltern ,  VII Sympos. German Society for Endocrinology ,  Springer Verlag ,  Berlin 1961 ,  119-123 Awards 1976 Faculty Scholar of the Josiah Macy Foundation during sabbatical leave at the ,  University of Geneva ,  ,  Switzerland 1977 Vuk Vrhovac Memorial Lecture University of Zagreb ,  Zagreb ,  Croatia (Hrvatska) 1980 Upjohn Lecturer of the Faculty of Health Sciences ,  University of Ottawa ,  ,  Canada 1985 Pfizer Lecturer and Travelling Fellow of the Clinical Research Institute ,  University of Montreal ,  ,  Canada 1985 Inaugural Banting and Best Memorial Lecture and Canadian Diabetes Association Award: 12th Congress of the International Diabetes Federation ,  Madrid ,  Spain 1986 Visiting Research Fellowship at Merton College ,  University of Oxford ,  Oxford ,  United Kingdom 1986 MRC Visiting Scientist Award during sabbatical leave ,  University of Oxford ,  Oxford ,  United Kingdom 1986 Elected Fellow of the Royal College of Physicians and Surgeons of Canada, Medical Scientist Category ,  ,  1989 JDFI Mary Kugel Award ,  1989 Canada Council Killam Scholar ,  ,  1990 Peter J. Laurie Memorial Lecture of the Juvenile Diabetes Foundation Canada ,  Toronto ,  Canada 1991 R. Kroc Lectureship ,  University of Southern California School of Medicine ,  Los Angeles ,  United States 1991 Banting Medal and Lectureship For Distinguished Scientific Achievement (American Diabetes Association) ,  ,  1992 Honorary Degree of Doctor of Medicine ,  Karolinska Institute Medical Faculty ,  ,  1992 Mizuno Inaugural Lectureship and Award, Fourth International Symposium on Exercise and Diabetes ,  Osaka University ,  ,  Japan 1992 Foreign Adjunct Professor ,  Karolinska Institute ,  Stockholm ,  Sweden 1994 Honorary Executive Member of the Croatian World Congress Physicians ,  ,  1994 Recognition for outstanding contributions to Juvenile Diabetes Foundation, ,  ,  Canada 1995 Honorary member of the Turkish Diabetes Association ,  ,  1995 Solomon A. Berson Distinguished Lectureship of American Physiological Society - Endocrinology and Metabolism Section, ,  FASEB, ,  Atlanta ,  1995 Novo Nordisk Lecture ,  Karolinska Institute ,  Stockholm ,  Sweden 1995 Poll Visiting Scholar ,  University of Washington ,  Seattle, Washington ,  United States 1997 Corresponding Member, ,  Croatian Academy of Arts and Sciences ,  ,  1997 Fellow, Royal Society of Canada (FRSC) ,  ,  2000 Citation for contributions to Medical Science and Health in Croatia, on the occasion of the 125th anniversary ,  Medical Council of Croatia ,  ,  AMAC Member Memberships All 1978 - 1979 President ,  Toronto Diabetes Association ,  ,  1975 - 1976 President ,  Toronto Clinical Research Society ,  ,  :: :: - :: :: honorary executive member ,  World Association of Croatian physicians ,  ,  :: :: - :: :: International Diabetes Federation ,  ,  :: :: - :: :: American Diabetes Association ,  ,  :: :: - :: :: American Physiological Society ,  ,  :: :: - :: :: Endocrine Society (USA) ,  ,  :: :: - :: :: New York Academy of Science ,  ,  :: :: - :: :: Canadian Society of Endocrinology ,  ,  :: :: - :: :: European Association for the Study of Diabetes ,  ,  :: :: - :: :: Sigma XI, The Scientific Research Society ,  ,  :: :: - :: :: Canadian Physiological Society ,  ,  :: :: - :: :: Canadian Society for Clinical Research ,  ,  :: :: - :: :: Canadian Diabetes Association ,  ,  :: :: - :: :: Alumni & Friends of MRC – Founding Group Member ,  ,  Pool   YES Cooperation   Znanstvena suradnja;Suradnja sa gospodarstvom;   Expertise Endocrinology and Diabetes Our interest for the last 45 years focused on carbohydrate metabolism and diabetes in four areas of research. 1) Tracer Methods for Quantifying Non-Steady State Glucose Turnover The main metabolic problem of diabetes is hyperglycemia which is caused by increased glucose production and decreased glucose utilization in muscle, fat, and the liver. Over the years, we pioneered tracer methods to measure glucose turnover in health and diabetes, and consequently the use of this methodology in animal and human experimentation skyrocketed. This methodology provided the cornerstone for studying the role of hormonal interactions in glucoregulation and launched many breakthroughs in the field of the pathogenesis of diabetes. The hormonal defects in diabetes are deficiency of insulin and excess of glucagon. We were the first to outline the interaction of these two hormones in regulating hepatic metabolism in rest and exercise. 2) Exercise and Diabetes Our lab has pioneered the role of exercise in physiology and diabetes, in both clinical and animal investigations. Interestingly, in insulin treated diabetic patients, exercise can lead to hypo- and hyperglycemia. We were the first to establish the mechanism of these abnormalities, which had major clinical implications. We demonstrated by tracer, cellular and molecular methods how mucle, liver and pancreatic cells adapt to hyperglycemia, a critical concept in diabetes. We described a unique homeostatic mechanism in which muscle is protected from over- and underutilization of glucose. This explains why muscle does not display diabetic complications. Because of those findings, we were invited to organize the first conference ever on diabetes and exercise. It is considered that this conference stimulated worldwide investigations that eventually led to the concept that exercise can not only ameliorate but also prevent the onset of diabetes. 3) Extrapancreatic Glucagon We demonstrated that the alpha cells of stomach mucosa of the dog synthesize and release extrapancreatic glucagon. This changed the prevailing views of the 1970’s, that a given hormone is only synthesized in a single gland. We purified this new hormone and demonstrated that it was indistinguishable from pancreatic glucagon, and that its cellular and physiological effects were identical. This finding was a milestone in endocrine research because it provided the first evidence of an extrapancreatic site of a pancreatic hormone. 4) Stress, Hypoglycemia and Diabetes We demonstrated a neuroendocrine pathway that increases glucose uptake during stress which is deficient in diabetes. This is why stress in diabetics can lead to a marked increase in plasma glucose. More recently, we elucidated the molecular mechanisms controlling brain gene expression of stress hormones and their receptors in response to diabetes and hypoglycemia.