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| Official Contact Inforamtion |
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Institution:
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University of London
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Department Name:
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Centre for Haematology, Institute of Cell and Molecular Science Bart’s & The London, Queen Mary’s School of Medicine,
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Position
:
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Professor
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Street And Number
:
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Medical College Building 1st Floor, Turner Street
,
London E1 2AD
,
United Kingdom
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Official Phone
,
Official Fax
:
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+44-20-7377 7000 (x3056)
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+44-20-7377 7629
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E-mail
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d.nizetic@qmul.ac.uk
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Web
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genetics (Biology.Natural Sciences)
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molecular biology (Biology.Natural Sciences)
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medical biochemistry (clinical medical sciences .Biomedicine and Public Health)
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medical microbiology (clinical medical sciences .Biomedicine and Public Health)
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| Education |
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1987
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Doktor
Prirodno-Matematicki Fakultet, Sveucilista u Beogradu
,
Bioloskih Znanosti,
Beograd
,
|
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1982
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Doktor
Medicinski Fakultet Sveucilista u Zagrebu
,
Medicine
Zagreb
,
Hrvatska (Croatia)
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Doktorat znanosti
u potpunosti uradjen u Max-Planck-Institutu za Biologiju
,
Tuebingen
,
Germany
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| Employment Positions |
|
2001
|
Professor of Cellular and Molecular Biology
Institute of Cell and Molecular Science, St.Bartholomew’s and The Royal London Medical School, Queen Mary,
University of London. Tenure Post
,
London
,
United Kingdom
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2000 - 2001
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Reader in Cell and Molecular Biology
Centre for Applied Molecular Biology
University of London, School of Pharmacy
,
London
,
United Kingdom
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1996 - 2000
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Senior Lecturer in Molecular Biology
Centre for Applied Molecular Biology
University of London, School of Pharmacy. Independent Research Group Leader
,
London
,
United Kingdom
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1994 - 1996
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Lecturer in Molecular Biology
Centre for Applied Molecular Biology
University of London, School of Pharmacy. Independent Research Group Leader
,
London
,
United Kingdom
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1987 - 1994
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Post-doctoral Research Fellowship
Genome Analysis Laboratory
Imperial Cancer Research Fund, London
,
London
,
United Kingdom
Head:Dr.H.Lehrach
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1982 - 1985
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Fellowship (Max-Planck Stipendium
Dept. of Immunogenetics
Max-Planck-Institute for Biology, Tuebingen, F.R.Germany,
,
,
Germany
Results from research during this fellowship were used as the experimental data for my PhD thesis, with the permission of the Director. Ph.D in Molecular Biology, Faculty of Science , University of Belgrade, Yugoslavia, 22/04/1987. Official Mentor: Prof. Radomir Crkvenjakov
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1979 - 1982
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Undergraduate research and student assistant (demonstrator)
Department of Physiology
University of Zagreb, Faculty of Medicine
,
Zagreb
,
Hrvatska (Croatia)
tutors: Prof. M.Marusic and Prof. F.Culo. Head of Department: Prof. N.Allegretti
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| Academic Positions |
| Teaching |
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2004
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Graduate School Programme in Genetics (Lecture on “Genetic Basis of Disease”)
,
,
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|
2003
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Problem Based Learning
Stage 2,
Metabolism System
,
,
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2003 - 2004
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Problem Based Learning, Term 2, Stage 1B, Cardiorespiratory System
,
,
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1998 - 1999
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“Molecular basis of disease” module in the 3rd year options Bpharm, course
,
Taught lectures
,
,
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1994 - 1998
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“Introduction to Molecular Genetics and Gene Therapy”
,
Designed and given 10 lectures in
,
,
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| Guest teacher |
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2002 - 2004
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“Visiting Professor” gave a Lecture,
“Genetic Basis of Disease”
,
School of Pharmacy, University of London
,
,
London
,
United Kingdom
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| Congres |
|
2004
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European Haematology Association Conference
,
,
Geneva
,
Switzerland
Abstract chosen among top 9% of abstracts for oral presentation delivered by my post-doc, Dr.Claire Mulligan
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2004
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First Croatian Conference on Down’s syndrome
,
,
Split
,
Hrvatska (Croatia)
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2003
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THIRD EUROPEAN-AMERICAN INTENSIVE COURSE IN CLINICAL AND FORENSIC GENETIC: ADVANCES IN MOLECULAR MEDICINE
,
,
Zagreb
,
Hrvatska (Croatia)
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|
2002
|
II International Conference on Chromosome 21 and Medical Research on Down Syndrome
,
,
Barcelona
,
Spain
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2001
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1st Congress of Croatian Oncological Society with International Participation
,
,
Zagreb
,
Hrvatska (Croatia)
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2001
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THE SECOND EUROPEAN-AMERICAN INTENSIVE COURSE IN CLINICAL AND FORENSIC GENETICS: MOLECULAR MEDICINE IN THE MILLENNIUM
,
Hotel Excelsior, Dubrovnik
,
,
Dubrovnik
,
Hrvatska (Croatia)
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|
1998
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2nd International Croatian Congress of Human Genetics
,
,
Zagreb
,
Hrvatska (Croatia)
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|
1997
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7th International workshop on Human Chromosome
,
,
Berlin
,
Germany
|
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1995
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2nd International workshop on Human Chromosome
,
,
Vienna
,
Austria
|
|
1994
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5th International workshop on Human Chromosome
,
,
Tsukuba (Tokyo)
,
Japan
|
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1994
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1st International Croatian Congress of Human Genetics
,
,
Zagreb
,
Hrvatska (Croatia)
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|
1993
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4th International workshop on Human Chromosome
,
,
Paris
,
France
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| Projects |
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2003 - 2006
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LRF-0356
,
Leukaemia Research Fund
,
£ 155,576
,
,
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2003 - 2005
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RAB/B&L-MDS
,
Special Trustees of St.Bartholomew’s and The Royal London Hospital
,
£ 89,267
,
,
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2003 - 2005
|
RAB/B&L-MDS
,
Special Trustees of St.Bartholomew’s and The Royal London Hospital
,
£ 89,267
,
,
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2002 - 2004
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FJL
,
Jerome Lejeune Foundation
,
£ 20,700 (€ 30,000)
,
,
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2002 - 2005
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RAC405/B&LMDS
,
Special Trustees of St.Bartholomew’s and The Royal London Hospital
,
£ 112,649 (joint with Dr.J.Groet)
,
,
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1999 - 2002
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CRC-SP 2475/0101
,
Cancer Research Campaign
,
£ 123,968
,
,
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1999 - 2002
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LRF-9838
,
Leukaemia Research Fund
,
£ 119,755
,
,
|
|
1996 - 1998
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BMH4-CT96-0554
,
Commission of European Communities grants to Consortia of EU Research Teams, the value listed is the share of the grant obtained by Dean Nizetic
,
£ 59,276 (ECU73,000)
,
,
|
|
1996 - 1999
|
BMH4-CT96-0319
,
Commission of European Communities grants to Consortia of EU Research Teams, the value listed is the share of the grant obtained by Dean Nizetic
,
£ 97,675 (ECU120,300)
,
,
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1996 - 1999
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G94226164
,
Medical Research Council
,
£ 276,697
,
,
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1995
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Towards puchase of an automated developer (Small equipment grant)
,
University of London Central Resource Fund
,
£ 2,500
,
,
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1995
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Transfer of technology (Construction of cosmid libraries from flow sorted chromosomes)
,
Sanger Centre
,
£30,000
,
,
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1994
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Travel to the invited chairmanship of the Conference Session (5th international workshop on human chromosome 21)
,
MRC (HGMP travel)
,
£ 900
,
,
|
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1994 - 1996
|
GENO-CT93-0062
,
Commission of European Communities grants to Consortia of EU Research Teams, the value listed is the share of the grant obtained by Dean Nizetic
,
£ 48,720 (ECU60,000)
,
,
|
|
1994 - 1996
|
GENO-CT93-0075
,
Commission of European Communities grants to Consortia of EU Research Teams, the value listed is the share of the grant obtained by Dean Nizetic)
,
£ 73,080 (ECU90,000)
,
,
|
|
1994 - 1996
|
GENO-CT93-0015
,
Commission of European Communities grants to Consortia of EU Research Teams, the value listed is the share of the grant obtained by Dean Nizetic)
,
£ 72,674 (ECU 89500)
,
,
|
| Publications |
| Articles |
Dean
Nizetic
|
Suzanne McElwaine, Claire Mulligan, Jürgen Groet (et al.)
Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down’s syndrome, revealing PRAME as a specific discriminating marker
,
British Journal of Haematology
,
2004
,
125
729-742
|
Dean
Nizetic
|
Jürgen Groet, Suzanne McElwaine, Monica Spinelli (et al.)
Acquired mutations in GATA1 in neonates with Down syndrome with Transient Myeloid Disorder
,
The Lancet
,
2003
,
361
1617-1620
|
Dean
Nizetic
|
Leonardo A. Meza-Zepeda, Anne Forus (et al.)
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21.
,
Oncogene
,
2002
,
21(14)
2261-2269
|
Dean
Nizetic
|
Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta, PK, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK.
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
,
Nature Genetics
,
2001
,
28(3)
220-221
|
Dean
Nizetic
|
Functional Genomics of the Down Syndrome
,
Review. Croatian Medical Journal
,
2001
,
42(4)
420-426
|
Dean
Nizetic
|
Adriana Cabral, Patrick Voskamp, Anne-Marie Cleton-Jansen, Andrew South, Claude Backendorf
Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function
,
Journal of Biological Chemistry
,
2001
,
276(22)
19231- 19237
|
Dean
Nizetic
|
Meza-Zepeda L.A., Berner J.M., Henriksen J., South A., Pedeutour F., Dahlberg A.B., Godager L.H., Forus A., Myklebost O.
Ectopic sequences from truncated HMGI C in liposarcomas are derived from various amplified chromosomal regions
,
Genes, Chromosomes and Cancer
,
2001
,
21
264-273
|
Dean
Nizetic
|
Strachan T., Smith M., Eichorn P., Tonkin E., Jones S., Ireland M., Simpson C., Krantz I., Jackson L.
Cloning of disease associated breakpoint regions at 3q26.3 and 21q11 in Cornelia de Lange syndrome patients with balanced de novo translocations.
,
Developmental Dynamics
,
2000
,
219:(3)
|
Dean
Nizetic
|
Tania A. Jones or Rachel H. Flomen, Gabrielle Senger, Denise Sheer.
The homeobox gene MEIS1 is amplified and/or highly expressed in at least four neuroblastoma cell lines
,
European Journal of Cancer, Eur J Cancer. Dec 1;
,
2000
,
36(18)
2368-2374
|
Dean
Nizetic
|
M. Hattori, A. Fujiyama, T. D. Taylor (et al.)
The DNA sequence of human chromosome 21
,
Nature
,
2000
,
405
311 - 319
|
Dean
Nizetic
|
Juergen Groet, Jane H. Ives, Tania A. Jones, Malcolm Danton, Rachel H. Flomen, Denise Sheer, Reno Hrascan, Kresimir Pavelic
Narrowing of the Region of Allelic Loss in 21q11-21 in Squamous Non-Small Cell Lung Carcinoma and Cloning of a Novel Ubiquitin Specific Protease Gene from the Deleted Segment
,
Genes, Chromosomes and Cancer Feb;
,
2000
,
27(2)
153-161
|
Dean
Nizetic
|
Wang, S-Y., Cruts, M., Del-Favero, J., Zhang, Y., Bosch, A., Chen, H.M., Bennett, L., Patterson, D., Potier, M.C., Estivill, X., Antonarakis, S.E., Kessling, A. & Van Broeckhoven, C.
A STS-based YAC contig map of human chromosome 21p ranging from the centromere to the rDNA gene cluster.
,
Genome Research Nov;
,
1999
,
9(11)
1059-1073
|
Dean
Nizetic
|
Andrew P. South, Adriana Cabral, Jane H. Ives,Colin H. James, Ghazala Mirza, Ingo Marenholz, Dietmar Mischke, Claude Backendorf, Jiannis Ragoussis,
Human Epidermal Differentiation Complex in a single 2.5 Mbp long continuum of overlapping DNA cloned in bacteria integrating physical and transcript maps.
,
Journal of Investigative Dermatology
,
1999
,
112(6)
910-918
|
Dean
Nizetic
|
M.-C. Potier, A. Dutriaux, R. Orti, J. Groet, N. Gibelin, G. Karadima, G. Luftalla, A. Lynn, C. Van Broeckhoven, A. Chakravarti, M. Petersen, J. Delabar, J. Rossier.
Two sequence-ready contigs spanning the two copies of a 200 kb duplication on 21q: partial sequence and polymorphisms
,
Genomics
,
1998
,
51(3)
417-426
|
Dean
Nizetic
|
N. Tripodis, R. Mason, S.J. Humphray, A.F.Davies, J.A. Herberg, J. Trowsdale, G.Senger, J.Ragoussis.
Physical map of human 6p21.2-6p21.3
,
Genome Research.
,
1998
,
8(6)
631-643
|
Dean
Nizetic
|
Maria Lioumi, Mark Olavesen, Jiannis Ragoussis
High resollution YAC fragmentation map of 1q21
,
Genomics
,
1998
,
49(2)
200-208
|
Dean
Nizetic
|
Simona Cavani, Chiara Perfumo, Alessandra Argusti, Mauro Pierluigi, Lucia Perroni, Finbarr E. Cotter, Michael B. Petersen, Paolo Strigini, Franca Dagna-Bricarelli
Cytogenetic and molecular study of 32 Down syndrome families: potential leukaemia predisposing role of the most proximal segment of chromosome 21q.
,
British Journal of Haematology
,
1998
,
103(1)
213-216
|
Dean
Nizetic
|
A.Egeo, M.Mazzocco, F.Sotgia, P.Arrigo, R.Oliva ,S.Bergonon, A.Rasore-Quartino & P.Scartezzini
Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein
,
Human Genetics
,
1998
,
102(3)
289-293
|
Dean
Nizetic
|
Jose Manuel Vidal-Taboada, Salvador Bergonon, Mayca Sanchez, Cristina Lopez-Acedo, Juergen Groet, Aliana Egeo, Paolo Scartezzini, Nicholas Katsanis, Elizabeth M.C. Fisher, Jean Maurice Delabar, Rafael Oliva
High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2.
,
Biochem. Biophys. Res. Comm.
,
1998
,
243(2)
572-578
|
Dean
Nizetic
|
Jane H. Ives, Franca Dagna-Bricarelli, Giuseppe Basso, Stylianos E. Antonarakis, Roger D. Jee, Finbarr E. Cotter,
Increased levels of a chromosome 21 encoded tumour invasion and metastasis factor (TIAM1) mRNA in bone marrow of Down syndrome children during the acute phase of AML(M7)
,
Genes, Chromosomes and Cancer.
,
1998
,
23
61-66
|
Dean
Nizetic
|
Juergen Groet, Jane H.Ives, Andrew P.South, Pedro R. Baptista, Tania A. Jones, Marie-Laure Yaspo, Hans Lehrach, Marie-Claude Potier, Christine Van Broeckhoven,
Bacterial contig map of the 21q11 region associated with Alzheimer’s disease and abnormal myelopoiesis in Down syndrome.
,
Genome Research
,
1998
8
385-398
|
Dean
Nizetic
|
R.H.Flomen, R.Vatcheva, P.Gorman, P.R.Baptista, J.Groet, I.Barisic, I.Ligutic,
Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks ~90 kbp upstream of this gene
,
Genomics
,
1998
,
47
409-413
|
Dean
Nizetic
|
Nicholas Katsanis, or Jane H. Ives, Juergen Groet, Elizabeth M.C. Fisher.
Localisation of Receptor Interacting Protein (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome
,
Human Genetics
,
1998
,
102
221-223
|
Dean
Nizetic
|
Jose Manuel Vidal-Taboada, Salvador Bergonon, Paolo Scartezzini, Aliana Egeo, Rafael Oliva.
High resolution physical map and identification of potentially regulatory sequences of the human SH3BGR located in the Down syndrome chromosomal region. Biochem
,
Biophys. Res. Comm.
,
1997
,
241
321-326
|
Dean
Nizetic
|
P.Scartezzini, A.Egeo, S.Collela, P.Fumagalli, P.Arrigo, R.Taramelli, A.Rasore-Quartino.
Cloning of a new human gene from chromosome 21q22.3 encoding a glutamic acid rich protein expressed in heart and skeletal muscle
,
Human Genetics
,
1997
,
99(3)
387-392
|
Dean
Nizetic
|
R.H.Flomen, P.Gorman, R.Vatcheva, J.Groet, I.Barisic, I.Ligutic, D.Sheer,
Rieger syndrome locus: a new reciprocal translocation t(4;12)(q25;q15) and a deletion del(4)(q25q27) both break between markers D4S2945 and D4S193
,
Journal of Medical Genetics
,
1997
,
34(3)
191-195
|
Dean
Nizetic
|
K.Osoegawa, R.Susukida, S.Okano, Y.Kato, H.Lehrach, E. Soeda.
Potential CpG-rich islands clustering around single-minded gene in Down syndrome critical region
,
Mammalian Genome
,
1996
,
7(6)
461-463
|
Dean
Nizetic
|
K.Osoegawa, R.Susukida, S.Okano, J.Kudoh, S.Minoshima, N.Shimizu, P.de Jong, J.Groet, J.Ives, H.Lehrach, E.Soeda.
An integrated map with cosmid/PAC contig of a 4 Mbp Down syndrome critical region
,
Genomics
,
1996
,
32(3)
375-387
|
Dean
Nizetic
|
A.Weith, G.M.Brodeur, G.A.P.Bruns, T.Cox Matise, D.Mischke, M.F.Seldin, N.van Roy, J.Vance
Report of the second international workshop on human chromosome 1 mapping 1995
,
Cytogenet.Cell Genet.
,
1996
,
72
113-154
|
Dean
Nizetic
|
M.Pierluigi, C.Perfumo, S.Cavani, F.Dagna-Bricarelli,
An improved method for the detection of Down’s syndrome aneuploidy in uncultured amniocytes
,
Clinical Genetics.
,
1996
,
49(2)
32-36
|
Dean
Nizetic
|
N. Tripodis, R. Mason, A.Davies, J.Ragoussis
Physical and transcription map of the 6p21.2-6p21.3 boundary region
,
DNA Seq.
,
1996
,
7(1)
53-54
|
Dean
Nizetic
|
M.G.Olavesen, A.F.Davies, J.S.Broxholme, J.L.Wixon, G.Senger, R.D. Campbell & J.Ragoussis.
An Integrated map of human chromosome 6p23.
,
Genome Research.
,
1995
,
5(4)
342-358
|
Dean
Nizetic
|
M-L.Yaspo, L.Gellen, R.Mott, B.Korn, A.Poustka, H. Lehrach
Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries
,
Human Molecular Genetics
,
1995
,
4(8)
1291-1304
|
Dean
Nizetic
|
N.Shimizu, S.Antonarakis, C.Van Broeckhoven, D.Patterson, K.Gardiner, N.Creau, J-M. Delabar, J.Korenberg, R.Reeves, J.Doering, O.Ritter & J.Cuticchia,
Report of the fifth international workshop on human chromosome 21 mapping 1994.
,
Cytogenet. and Cell Genet.
,
1995
,
70
147-182
|
Dean
Nizetic
|
S.Monard, F.Cotter, B.D.Young & H.Lehrach,
Construction of cosmid libraries from flow sorted material of human chromosomes 1,6,7,11,13 and 18 for use as reference libraries
,
Mammalian Genome
,
1994
,
5(12)
801-802
|
Dean
Nizetic
|
S.Volinia, I.Hiles, E.Ormondroyd, R.Antonacci, M.Rocchi & M.D.Waterfield,
Molecular Cloning, cDNA Sequence, and Chromosomal Localization of the Phosphatidylinositol 3-Kinase p110alpha (PIK3CA)
,
Gene. Genomics
,
1994
,
24
472-477
|
Dean
Nizetic
|
J. Kumlien, T.Labella, G.Zehetner, R.Vatcheva, H.Lehrach,
Efficient identification and regional positioning of YAC and cosmid clones to human chromosome 21 by radiation fusion hybrids
,
Mammalian Genome
,
1994
,
5(6)
365-371
|
Dean
Nizetic
|
A.Dutriaux, J.Rossier, W.Van Hul, D.Theophille, J.M.Delabar, C.Van Broeckhoven & M.C.Potier,
Cloning and characterization of a 135-500 kb region of homology on the long arm of human chromosome 21.
,
Genomics
,
1994
,
22
481-483
|
Dean
Nizetic
|
L.Gellen, R.Hamvas, R.Mott, A.Grigoriev, R.Vatcheva, G.Zehetner, M.L.Yaspo, A.Dutriaux, C.Lopes, J.M.Delabar, C. Van Broeckhoven, M.C.Potier, H.Lehrach;
An integrated YAC overlap and "cosmid-pocket" map of the human chromosome 21
,
Human Molecular Genetics
,
1994
,
3(5)
759-770
|
Dean
Nizetic
|
L. Hawthorn, H.Lehrach, J.K.Cowell,:
Assignment of 55 novel cosmids to 7 subregions of chromosome 13 using fluorescence in situ hybridisation
,
Genomics
,
1994
,
21
248-250
|
Dean
Nizetic
|
R.M.J. Hamvas, F.Francis, R.Cox, M.E.Goldsworthy, S.D.M.Brown, H.Lehrach;
Rapid restriction analysis of YAC clones
,
Nucleic Acids Res.
,
1994
,
22(7)
1318-1319
|
Dean
Nizetic
|
J.M.Meerabux, F.E.Cotter, L.Kearney, S.Dhut, B.Gibbons, T.A.Lister & B.D.Young;
Molecular cloning of a novel 11q23 breakpoint associated with non-Hodgkin's lymphoma
,
Oncogene
,
1994
9
893-898
|
Dean
Nizetic
|
J.-M.Delabar, N.Creau, P.-M.Sinet, O.Ritter, S.E.Antonarakis, M.Burmeister, A.Chakravarti, M.Ohki, D.Patterson, M.B.Petersen, R.H.Reeves, C.Van Broeckhoven,:
Report of the Fourth International Workshop on human chromosome 21
,
Genomics
,
1993
,
18
735-744
|
Dean
Nizetic
|
J.D.Hoheisel, E.Maier, R.Mott, L.McCarthy, A.V.Grigoriev, L.C.Schalkwyk, F.Francis, H.Lehrach;
High resolution cosmid and P1 maps spanning the 14 Mbp genome of the fission yeast S.Pombe
,
Cell
,
1993
,
73
109-120
|
Dean
Nizetic
|
M.T.Ross, C.Nguyen, C.Knights, R.Vatcheva, N.Burden, C.Douglas, G.Zehetner, D.C.Ward, A.Baldini, H.Lehrach;
Selection of a YAC sub-library enriched for human chromosome 21 by hybridisation with a chromosome specific composite probe
,
Nature Genetics
,
1992
1
284-290
|
Dean
Nizetic
|
A. Baldini, M.Ross, R.Vatcheva, E.A.Lindsay, H.Lehrach, M.Siniscalco;
Chromosomal assignment of human YAC clones by fluorescence in situ hybridisation. Use of single-yeast-colony-PCR and multiple labelling.
,
Genomics
,
1992
,
14
181-184
|
Dean
Nizetic
|
A.P.Monaco, V.M.S.Lam, G.Zehetner, G.G.Lennon, C.Douglas, P.N.Goodfellow and H.Lehrach,
Mapping irradiation hybrids to cosmid and yeast artificial chromosome libraries by direct hybridisation of Alu-PCR products.
,
Nucleic Acids Res.
,
1991
,
19
3315-3318
|
Dean
Nizetic
|
R.Drmanac ; H.Lehrach,
An improved colony lysis procedure enables direct DNA hybridisation using short (10,11 bases) oligonucleotides to cosmids
,
Nucleic Acids Res.
,
1991
,
19
182
|
Dean
Nizetic
|
G.Zehetner, A.P.Monaco, L.Gellen, B.D.Young ; H.Lehrach,
Construction, arraying and high density screening of large insert libraries of the human chromosomes X and 21: their potential use as reference libraries
,
Proc. Natl. Acad. Sci. USA.
,
1991
,
88
3233-3237
|
Dean
Nizetic
|
R.Drmanac, G.G.Lennon, A.Beitverda ; H.Lehrach,
W (A or T) sequences as probes and primers suitable for genomic mapping and fingerprinting.
,
Nucleic Acids Res.
,
1991
,
19
5839-5842
|
Dean
Nizetic
|
J.D.Hoheisel, R. Drmanac, Z.Larin, G.Lennon, A.P.Monaco, M.Ross, G.Zehetner & H.Lehrach,:
Use of high coverage libraries for an integrated analysis of genomic DNA
,
BTF6, Advances in Mol.Genet.
,
1991
4
125-132
|
Dean
Nizetic
|
A.G.Craig ; J.D.Hoheisel ; G.Zehetner ; H.Lehrach,:
Ordering of cosmid clones covering the Herpes simplex virus type I (HSV-1) genome: a test case for fingerprinting by hybridisation.
,
Nucleic Acids Res.
,
1990
,
18(9)
2653-2660
|
Dean
Nizetic
|
J.D.Hoheisel ; H.Lehrach,
Control of partial digestion combining the enzymes dam methylase and Mbo I.
,
Nucleic Acids Res.
,
1989
,
17(23)
9571-9582
|
Dean
Nizetic
|
A.G.Craig ; H.Lehrach,:
Labelling oligonucleotides to high specific activity (I).
,
Nucleic Acids Res.
,
1989
,
17(12)
4605-4610
|
Dean
Nizetic
|
M. Stevanovic ; B. Soldatovic ; I. Savic ; R. Crkvenjakov,
Limited polymorphism of both classes of MHC genes in four different species of the Balkan mole rats.
,
Immunogenetics
,
1988
,
28
91-98
|
Dean
Nizetic
|
V.Vincek, M.Golubic, F.Figueroa, E.Nevo and J.Klein,:
Evolutionary expansion of MHC class I loci in the mole-rat, Spalax ehrenbergi
,
Mol. Biol. Evol.
,
1987
,
4(5)
483-491
|
Dean
Nizetic
|
R.Schoepfer ; F.Figueroa ; E.Nevo ; J.Klein,
Evolutionary diversification of class II P loci in the MHC of the mole-rat Spalax ehrenbergi.
,
Mol. Biol. Evol.
,
1987
,
4(3)
287-299
|
Dean
Nizetic
|
F.Figueroa ; Z.Dembic ; E.Nevo ; J.Klein,:
Major histocompatibility complex gene organization in the mole rat Spalax ehrenbergi: evidence for transfer of function between class II genes.
,
Proc. Natl. Acad. Sci. USA
,
1987
,
84
5828-5832
|
Dean
Nizetic
|
F. Figueroa ; M. Golubic, ; J. Klein,
Evolution of mouse major histocompatibility complex genes borne by t chromosomes.
,
Proc. Natl. Acad. Sci. USA
,
1985
,
82
2819-2823
|
Dean
Nizetic
|
F. Figueroa ; E. Nevo ; J. Klein,
Major histocompatibility complex of the mole-rat. II. Restriction fragment polymorphism
,
Immunogenetics
,
1985
,
22
55-67
|
Dean
Nizetic
|
F.Figueroa, H.J.Mueller, B.Arden, E.Nevo and J.Klein,
Major histocompatibility complex of the mole-rat. I. Serological and biochemical analysis
,
Immunogenetics
,
1984
,
20
443-451
|
Dean
Nizetic
|
F.Figueroa ; J. Klein,
Evolutionary relationships between the t and H-2 haplotypes in the house mouse
,
Immunogenetics
,
1984
,
19
311-320
|
| Serials |
|
Dean
Nizetic
|
H. Lehrach
Chromosome specific gridded cosmid libraries : construction, handling and use in parallel and integrated mapping. In:
,
DNA cloning 3 - complex genomes: A practical approach.; eds: D.Hames & D.Glover
,
IRL, Oxford University Press
,
Oxford UK
1995
,
49-79
|
|
Dean
Nizetic
|
G.Zehetner ; H.Lehrach,
The ICRF cosmid reference libraries. In:
,
“Human Genome Analysis Programme”; ed: M.Hallen
,
IOS-Press
,
Amsterdam
1995
,
8:21-24
|
|
Dean
Nizetic
|
M.-L.Yaspo, P.Sanseau, B.Korn, A. Poustka & H.Lehrach;
Integrated transcriptional maps of large DNA regions: towards a transcriptional map of human chromosome 21. In:
,
Proc. 3rd International Workshop on the Identification of Transcribed Sequences. ; ed: U.Hochgeschwender & K.Gardiner,
,
Plenum Press
1994
,
213-228
|
|
Dean
Nizetic
|
H.Lehrach, R.Drmanac, J.D.Hoheisel, Z.Larin, G.Lennon, A.P.Monaco, G.Zehetner and A.Poustka,
Hybridisation fingerprinting in genome mapping and sequencing. In:
,
Genome Analysis, eds. K.E.Davies & S.Tilghman.
,
Cold Spring Harbor Laboratory Press
,
Cold Spring Harbor (NY)
1990
,
39-81
|
|
Dean
Nizetic
|
A.G.Craig, J.D.Hoheisel, A.P.Monaco, G.Zehetner, G.Lennon, G.D.Young ; H.Lehrach,
Long-range ordering of clones by probe fingerprinting. In:
,
Current Communications In Molecular Biology. Polymerase Chain Reaction
,
Spring Harbor Laboratory Press
,
New York
1990
,
1-6
|
| Awards |
|
1986
|
Nagrada “Sedam sekretara SKOJ-a”, Zagreb
,
|
|
2001
|
za dostignuca na polju Molekulske Genetike
,
Drzavna Nagrada za Znanost Republike Hrvatske
Zagreb
,
Hrvatska (Croatia)
|
| AMAC |
|
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Member
,
AMAC Vel. Britanije (AMAC-UK), Osnivacki Tajnik istog ogranka AMAC
|
| Memberships All |
| Pool |
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YES
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| Cooperation |
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Znanstvena suradnja;Suradnja sa gospodarstvom;
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| Expertise |
Dr. Nizetic was one of the first scientists who cloned single, isolated human chromosomes in the form of genomic DNA libraries which were gridded and permanently stored, the well known ICRF-reference library system, which helped mapping many individual chromosomes DNA-s in the human genome project.
In 1994, Dr. Nizetic founded his independent research group. The group made a major contribution towards the final molecular map of the human chromosome 21, which culminated in the inclusion as a co-author of the historic paper on May 18th, 2000, in which the complete DNA sequence of human chromosome 21 has been published. This was only the second human chromosome to be completely sequenced.
Prof. Nizetic focussed on detection and characterization of genes from human chromosome 21, and their dose effects causing Down syndrome with all its interesting phenotypic features, such as childhood leukaemia, neuronal development abnormalities and Alzheimer’s disease.
In collaboration with Prof. K. Pavelic and his team at the “Rudjer Boskovic Institute” and with the use of the Croatian Tumour Bank, sponsored by the Croatian Academy of Sciences, the group of Prof. Nizetic cloned a novel gene, a ubiquitin specific protease, from the minimal region of deletions in lung cancer.
In 2003, Prof. Nizetic’s group was the first to discover that the acquired mutations in the transcription factor GATA1 occur in utero, and lead to the transient myeloproliferative disorder, but do not predict the onset or the prognosis of the ensuing acute megakaryoblastic leukaemia in Down syndrome children. Recently, Prof. Nizetic’s group completed the global transcriptome analysis using Affymetrix microarray (Gene Chip System). A new marker was discovered, specific for the progressive type of the leukaemic cells. This marker molecule has the potential to be exploited for therapeutic purposes. These results were published recently in Lancet and Brit. J. Haematology.
Recently, a transchromosomal embryonic stem cell model project to map the gene-dose effects of trisomy 21 was started by Prof. Nizetic’s group.
Molekulska Biologija, Stanicna Biologija, Molekulska Genetika, Funkcijska Genomika, Molekulska Medicina, Eksperimentalna Hematologija, Onkologija, Biologija Maticnih Stanica i njihova primjena u Medicini
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